p-Y420-FYN is phosphorylated on S21

Stable Identifier
R-HSA-5218854
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FYN has multiple phosphorylation sites which can affect its kinase activity. Among these phosphorylation sites, serine 21 (S21) has been identified as a target site for protein kinase A (PKA). The phosphorylation of FYN S21 is critical for both FYN's tyrosine kinase activity and its focal adhesion targeting (Yeo et al. 2007).

Literature References
PubMed ID Title Journal Year
20658524 Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration

Yeo, MG, Oh, HJ, Cho, HS, Chun, JS, Marcantonio, EE, Song, WK

J. Cell. Physiol. 2011
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Protein kinase A catalytic subunit [cytosol]
Physical Entity
Activity
Orthologous Events
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Created