Anthrax lef cleaves target cell MAP2K4 (MEK4)

Stable Identifier
R-HSA-5211391
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
cytosol
ReviewStatus
5/5
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Anthrax lef cleaves target cell MAP2K4 (MEK4)
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lef (Anthrax LF, lethal factor) a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K4 (MEK4, mitogen activated protein kinase kinase 4) (Vitale et al. 2000).
Literature References
PubMed ID Title Journal Year
11104681 Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor

Mock, M, Napolitani, G, Montecucco, C, Bernardi, L, Vitale, G

Biochem. J. 2000
7854123 Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Klimpel, KR, Leppla, SH, Arora, N

Mol. Microbiol. 1994
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Catalyst Activity

metallopeptidase activity of lef [cytosol]

Physical Entity
lef [cytosol] (Bacillus anthracis)
Activity
metallopeptidase activity (GO:0008237)
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-11)
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