Reactome | p-Y297,304,307-PRMT5 [nucleoplasm]

p-Y297,304,307-PRMT5 [nucleoplasm]

Stable Identifier

R-HSA-5211300

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

JBP1

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External Reference Information

External Reference

UniProt:O14744 PRMT5

Gene Names

PRMT5, HRMT1L5, IBP72, JBP1, SKB1

Chain

initiator methionine:1, chain:1-637, chain:2-637

Reference Genes

BioGPS Gene:10419 PRMT5

COSMIC (genes):PRMT5 PRMT5

CTD Gene:10419 PRMT5

dbSNP Gene:10419 PRMT5

ENSEMBL:ENSG00000100462 PRMT5

HGNC:10894 PRMT5

KEGG Gene (Homo sapiens):10419 PRMT5

Monarch:10419 PRMT5

NCBI Gene:10419 PRMT5

OMIM:604045 PRMT5

UCSC:O14744 PRMT5

Reference Transcript

Other Identifiers

0001570253

10419

11755951_s_at

12459

1564520_s_at

1564521_x_at

16790556

217786_at

3556925

3556926

3556927

3556928

3556929

3556931

3556934

3556935

3556937

3556938

3556939

3556940

3556941

3556942

3556943

3556945

3556946

3556948

3556950

3556952

3556953

3556954

3556955

3556956

3556957

3556958

3556959

3556960

4GQB

4X60

4X61

4X63

5525

56550_at

57340_s_at

5C9Z

5EMJ

5EMK

5EML

5EMM

5FA5

64708

6CKC

7977820

A_23_P76851

A_24_P298420

AAB66581

AAF04502

AAH25979

AB451246

AB451370

AF015913

AF015913_at

AF167572

AK075251

AK301812

AK302240

AL132780

BAG52095

BAG63261

BAG63592

BAG70060

BAG70184

BC005820

BC025979

C9JSX3

CAB012459

CAG33022

CCDS41922

CCDS61394

CCDS61395

CCDS61396

CCDS9579

CH471078

CR456741

EAW66218

EAW66219

EAW66220

EAW66221

ENSG00000100462

ENSP00000216350

ENSP00000319169

ENSP00000380582

ENSP00000380583

ENSP00000452555

ENST00000216350

ENST00000216350.12

ENST00000324366

ENST00000324366.12

ENST00000397440

ENST00000397440.8

ENST00000397441

ENST00000397441.6

ENST00000553897

ENST00000553897.5

EntrezGene:10419

EntrezGene:PRMT5

G3V2F5

G3V2L6

G3V2X6

G3V3A3

G3V507

G3V580

G3V5L5

G3V5T6

g5174682_3p_at

g5174682_3p_s_at

GE61958

GO:0000278

GO:0000387

GO:0002039

GO:0003674

GO:0003677

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006259

GO:0006325

GO:0006353

GO:0006397

GO:0006464

GO:0006479

GO:0007049

GO:0007088

GO:0007165

GO:0008150

GO:0008168

GO:0008327

GO:0008469

GO:0009058

GO:0016274

GO:0016740

GO:0018216

GO:0019918

GO:0022607

GO:0022618

GO:0030154

GO:0032259

GO:0032922

GO:0032991

GO:0034641

GO:0034709

GO:0034969

GO:0035097

GO:0035243

GO:0035246

GO:0042118

GO:0042802

GO:0043021

GO:0043226

GO:0043985

GO:0044020

GO:0044030

GO:0044877

GO:0045596

GO:0046982

GO:0048511

GO:0048714

GO:0048856

GO:0051276

GO:0065003

GO:0070372

GO:0070888

GO:0090161

GO:0097421

GO:0140014

GO:1901796

GO:1903507

GO:1904992

H0YJ77

H0YJD3

H0YJX6

HGNC:10894

HPA005525

HPA064708

ILMN_1811955

ILMN_2403889

IPR007857

IPR025799

IPR029063

IPR035075

IPR035247

IPR035248

MIM:604045

NM_001039619

NM_001282953

NM_001282954

NM_001282955

NM_001282956

NM_006109

NP_001034708

NP_001269882

NP_001269883

NP_001269884

NP_001269885

NP_006100

PF05185

PF17285

PF17286

PH_hs_0017523

PRMT5

PRMT5-201

PRMT5-202

PRMT5-203

PRMT5-204

PRMT5-213

TC14000940.hg

UPI000006F09F

UPI0000141374

UPI000015D937

UPI00017A82EE

UPI0001AE6957

XR_001750113

XR_429287

Participant Of

output

PRMT5 is tyrosine phosphorylated by JAK2 V617F

This entity regulates

Negatively

PRMT5 binds WDR77

Other forms of this molecule

PRMT5 [nucleoplasm]

PRMT5 [cytosol]

Inferred To

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Canis familiaris)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Danio rerio)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Drosophila melanogaster)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Mus musculus)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Rattus norvegicus)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Sus scrofa)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 297

Coordinate

297

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 304

Coordinate

304

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 307

Coordinate

307

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001269882.1, NP_001034708.1, NP_006100.2, NP_001269884.1, NP_001269885.1

OpenTargets

ENSG00000100462

IntEnz

2.1.1.320

ZINC - Substances

ANM5_HUMAN

GeneCards

O14744

ZINC target

O14744

PRO

O14744

ZINC - Predictions - Purchasable

ANM5_HUMAN

HMDB Protein

HMDBP01721

PDB

5EMK, 5EMM, 4X63, 6K1S, 5C9Z, 5EML, 4X60, 4GQB, 5FA5, 5EMJ, 6CKC, 4X61

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602)	0.96	17
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.777	8
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.756	6
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.693	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.646	3
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.646	8
UniProt:Q86U06 RBM23			0.635	3
UniProt:Q91XC0 Ajuba	3	phospho-p-S-AJUBA [cytosol] (R-MMU-2574841) Ajuba [nucleoplasm] (R-MMU-5687969) AJUBA [cytosol] (R-MMU-2564698)	0.623	4
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.616	6
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.611	4
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) SUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.602	4
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.591	3
UniProt:P24928 POLR2A	7	p-S5,S7-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5-POLR2A [nucleoplasm] (R-HSA-77100) POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5-POLR2A [nucleoplasm] (R-HSA-6781855)	0.558	6
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q86UQ8-1 NFE4			0.525	2
UniProt:P31269 HXA9			0.524	4
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960) GTPBP2 [extracellular region] (R-HSA-8863001)	0.508	2
UniProt:Q8WVJ2 NUDC2			0.508	2
UniProt:Q8TE85 GRHL3			0.508	2
UniProt:Q8N8U2 CDYL2			0.508	2
UniProt:Q96RU7 TRIB3	3	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.508	2
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.499	4
UniProt:Q16526 CRY1	4	CRY1 [cytosol] (R-HSA-400247) Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.499	3
UniProt:P03418 NCAP			0.499	2
UniProt:Q9NX04 CA109			0.488	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.488	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.488	2
UniProt:O15197-2 EPHB6			0.488	2
UniProt:Q14241 ELOA	1	TCEB3 [nucleoplasm] (R-HSA-112421)	0.488	2
UniProt:Q63ZY3 KANK2			0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.488	2
UniProt:Q96E35 ZMY19			0.488	2
UniProt:Q08289 CACNB2	2	CACNB2 [cytosol] (R-HSA-210496) CACNB2 [plasma membrane] (R-HSA-532200)	0.488	2
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.462	3
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.462	2