Parkin promotes the ubiquitination of mitochondrial substrates

Stable Identifier
R-HSA-5205682
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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Parkin promotes the ubiquitination of mitochondrial substrates
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Parkin promotes the ubiquitination of the mitofusin mitochondrial assembly regulatory factor (MARF), mitofusin 1, mitofusin 2 and voltage-dependent anion-selective channel protein 1 (vDAC1), all of which are embedded in the MOM.
Literature References
PubMed ID Title Journal Year
19432818 Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63

Kanthasamy, AG, Anantharam, V, Sun, F, Kanthasamy, A

J. Cell. Mol. Med. 2009
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of PRKN:PINK1 [mitochondrial outer membrane]

Physical Entity
PRKN:PINK1 [mitochondrial outer membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Parkin promotes the ubiquitination of mitochondrial substrates (Bos taurus)
Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)
Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)
Parkin promotes the ubiquitination of mitochondrial substrates (Mus musculus)
Parkin promotes the ubiquitination of mitochondrial substrates (Rattus norvegicus)
Authored
Gillespie, ME  (2013-11-21)
Reviewed
Chauss, D  (2015-09-01)
Kantorow, M  (2015-09-01)
Created
Gillespie, ME  (2013-12-05)
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