Reactome | BCL2 [mitochondrial outer membrane]

BCL2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-50757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Bcl-2 protein

Locations in the PathwayBrowser for interactor UniProt:Q13794 PMAIP1

Expand all

External Reference Information

External Reference

UniProt:P10415 BCL2

Gene Names

BCL2

Chain

chain:1-239

Reference Genes

BioGPS Gene:596 BCL2

COSMIC (genes):BCL2 BCL2

CTD Gene:596 BCL2

dbSNP Gene:596 BCL2

ENSEMBL:ENSG00000171791 BCL2

HGNC:990 BCL2

KEGG Gene (Homo sapiens):596 BCL2

Monarch:596 BCL2

NCBI Gene:596 BCL2

UCSC:P10415 BCL2

Reference Transcript

Other Identifiers

0003440484

0105860538

11721374_a_at

11721375_a_at

11721376_at

11721377_x_at

11738350_a_at

11738351_x_at

16855673

1847_s_at

1909_at

1910_s_at

1G5M

1GJH

1YSW

203684_s_at

203685_at

2038_g_at

207005_s_at

244035_at

2O21

2O22

2O2F

2W3L

2XA0

3811353

3811354

3811355

3811356

3811357

3811358

3811359

3811360

3811361

3811362

3811363

3811364

3811432

3811433

3811434

3811435

3811436

3811437

3811438

3811439

3811440

3811441

3811442

3811443

3811444

3811445

3811446

3811447

3811448

3811449

3811450

4AQ3

4IEH

4LVT

4LXD

4MAN

55295

596

5AGW

5AGX

5FCG

5JSN

5VAU

5VAX

5VAY

60568_at

6GL8

8023646

A0A024R2B3

A0A024R2C4

A_23_P208132

A_23_P352266

A_33_P3355185

AAA35591

AAA51813

AAA51814

AAD14111

AAH27258

AAO26045

AC021803

AC022726

AY220759

BC027258

BCL2

BCL2-201

BCL2-202

BCL2-203

CAA29778

CAB000003

CCDS11981

CCDS45882

CH471096

EAW63136

EAW63137

EAW63138

EAW63139

ENSG00000171791

ENSP00000329623

ENSP00000381185

ENSP00000466417

ENST00000333681

ENST00000398117

ENST00000398117.1

ENST00000589955

ENST00000589955.2

EntrezGene:596

EntrezGene:BCL2

g179366_3p_a_at

g4557354_3p_at

g4557356_3p_a_at

g4557356_3p_x_at

GE57834

GE848299

GO:0000003

GO:0000209

GO:0000278

GO:0000902

GO:0001503

GO:0001541

GO:0001656

GO:0001657

GO:0001658

GO:0001662

GO:0001776

GO:0001782

GO:0001822

GO:0001836

GO:0001952

GO:0002020

GO:0002260

GO:0002320

GO:0002326

GO:0002360

GO:0002376

GO:0002520

GO:0002931

GO:0003014

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005783

GO:0005789

GO:0005829

GO:0006464

GO:0006470

GO:0006582

GO:0006808

GO:0006810

GO:0006874

GO:0006914

GO:0006915

GO:0006950

GO:0006959

GO:0006974

GO:0006979

GO:0007005

GO:0007010

GO:0007015

GO:0007049

GO:0007155

GO:0007165

GO:0007409

GO:0007565

GO:0007568

GO:0007569

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0008584

GO:0008625

GO:0008630

GO:0008631

GO:0008637

GO:0009056

GO:0009058

GO:0009314

GO:0009636

GO:0009791

GO:0009887

GO:0010039

GO:0010224

GO:0010332

GO:0010468

GO:0010506

GO:0010507

GO:0010523

GO:0010559

GO:0014031

GO:0014042

GO:0014911

GO:0015267

GO:0016020

GO:0016021

GO:0016248

GO:0018105

GO:0018107

GO:0019221

GO:0019748

GO:0019899

GO:0019903

GO:0021700

GO:0021747

GO:0022607

GO:0022612

GO:0022857

GO:0022898

GO:0030097

GO:0030154

GO:0030183

GO:0030217

GO:0030279

GO:0030307

GO:0030308

GO:0030318

GO:0030336

GO:0030890

GO:0031069

GO:0031103

GO:0031625

GO:0031647

GO:0031965

GO:0031966

GO:0032469

GO:0032835

GO:0032848

GO:0032880

GO:0032991

GO:0033033

GO:0033077

GO:0033138

GO:0033689

GO:0034097

GO:0034330

GO:0035094

GO:0035265

GO:0040007

GO:0040008

GO:0040011

GO:0040018

GO:0042100

GO:0042149

GO:0042493

GO:0042542

GO:0042592

GO:0042802

GO:0042803

GO:0042981

GO:0043029

GO:0043066

GO:0043067

GO:0043085

GO:0043209

GO:0043226

GO:0043375

GO:0043473

GO:0043496

GO:0043497

GO:0043524

GO:0043565

GO:0043583

GO:0044403

GO:0045069

GO:0045636

GO:0045930

GO:0046671

GO:0046902

GO:0046930

GO:0046982

GO:0048041

GO:0048066

GO:0048070

GO:0048087

GO:0048536

GO:0048538

GO:0048545

GO:0048546

GO:0048589

GO:0048599

GO:0048743

GO:0048753

GO:0048856

GO:0048870

GO:0048873

GO:0050790

GO:0050853

GO:0051384

GO:0051402

GO:0051434

GO:0051607

GO:0051721

GO:0051726

GO:0051881

GO:0051902

GO:0051924

GO:0055085

GO:0061024

GO:0070059

GO:0070491

GO:0071310

GO:0071456

GO:0072593

GO:0097192

GO:0098609

GO:1900740

GO:1902166

GO:2000134

GO:2000378

GO:2000811

GO:2001234

GO:2001240

GO:2001243

GO:2001244

HGNC:990

HPA055295

Hs.46996.0.A1_3p_at

ILMN_1697970

ILMN_1701120

ILMN_1801119

ILMN_2246956

ILMN_2363250

IPR002475

IPR003093

IPR004725

IPR013278

IPR020717

IPR020726

IPR020728

IPR020731

IPR026298

IPR036834

M13994

M13994_s_at

M13995

M14745

M14745_at

MIM:151430

NM_000633

NM_000657

NP_000624

NP_000648

PF00452

PF02180

PH_hs_0004581

PR01862

PR01863

S72602

SM00265

SM00337

TC18000554.hg

TC18000952.hg

UPI000000D90E

UPI0000201E41

X06487

Participant Of

output

hasMember

Bcl-2/Bcl-X(L) [mitochondrial outer membrane]

hasComponent

input

Inferred To

BCL2 [mitochondrial outer membrane] (Bos taurus)

BCL2 [mitochondrial outer membrane] (Caenorhabditis elegans)

BCL2 [mitochondrial outer membrane] (Canis familiaris)

BCL2 [mitochondrial outer membrane] (Danio rerio)

BCL2 [mitochondrial outer membrane] (Gallus gallus)

BCL2 [mitochondrial outer membrane] (Mus musculus)

BCL2 [mitochondrial outer membrane] (Rattus norvegicus)

BCL2 [mitochondrial outer membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000648.2, NP_000624.2

OpenTargets

ENSG00000171791

ZINC - Substances

BCL2_HUMAN

ZINC target

P10415

ZINC - Biogenic

BCL2_HUMAN

PRO

P10415

PDB

5VAU, 5AGW, 2O21, 1G5M, 4IEH, 1GJH, 5VAY, 5FCG, 5VAX, 2O22, 1YSW, 6O0K, 5JSN, 5AGX, 4AQ3, 6GL8, 2W3L, 6O0M, 4LXD, 6O0L, 2O2F, 4MAN, 4LVT, 6O0P, 2XA0, 6O0O

ZINC - Investigational

BCL2_HUMAN

ZINC - Metabolites

BCL2_HUMAN

GeneCards

P10415

ZINC - Predictions - Purchasable

BCL2_HUMAN

Orphanet

15362

HMDB Protein

HMDBP02442

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14457 BECN1	3	p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.951	18
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX [cytosol] (R-HSA-139916) BAX activated [cytosol] (R-HSA-139907)	0.938	13
UniProt:O43521 BCL2L11	7	p-S65-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11-BRAF fusion [cytosol] (R-HSA-6802276) p-BCL2L11-BRAF fusion [cytosol] (R-HSA-6802519) BCL2L11 [cytosol] (R-HSA-2976673) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525)	0.918	8
UniProt:P55957 BID	4	BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953) MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373)	0.869	9
UniProt:Q9BXH1 BBC3	2	BBC3 [cytosol] (R-HSA-140220) BBC3 [mitochondrial outer membrane] (R-HSA-140222)	0.815	6
UniProt:Q92934 BAD	4	BAD [mitochondrial outer membrane] (R-HSA-114242) p-S128-BAD [cytosol] (R-HSA-217297) p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662)	0.807	5
UniProt:Q13323 BIK			0.802	5
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.746	13
UniProt:Q61337 Bad	6	BAD [mitochondrial outer membrane] (R-MMU-114242) phospho-p-S128-BAD [cytosol] (R-MMU-217297) p-S136-Bad [cytosol] (R-MMU-3139049) Bad [cytosol] (R-MMU-3139043) phospho-p-S99-BAD [cytosol] (R-MMU-198335) BAD [cytosol] (R-MMU-50662)	0.722	6
UniProt:O43521-2 BCL2L11			0.713	4
UniProt:O43521-1 BCL2L11			0.702	3
UniProt:P22736 NR4A1	2	NR4A1 [nucleoplasm] (R-HSA-199831) p-S351-NR4A1 [nucleoplasm] (R-HSA-199846)	0.674	7
UniProt:Q9C0C7 AMBRA1	2	AMBRA1 [cytosol] (R-HSA-1632831) p-AMBRA1 [cytosol] (R-HSA-1632854)	0.668	10
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.655	10
UniProt:Q91ZE9	3	phospho-p-BMF [mitochondrial outer membrane] (R-MMU-3145026) BMF [plasma membrane] (R-MMU-140209) phospho-p-BMF(1-89) [cytosol] (R-MMU-140529)	0.623	2
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.609	3
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.589	3
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.564	5
UniProt:Q8N5K1 CISD2			0.544	2
UniProt:Q13794 PMAIP1	2	PMAIP1 [cytosol] (R-HSA-140215) PMAIP1 [mitochondrial outer membrane] (R-HSA-140218)	0.524	3
UniProt:P11881	2	ITPR1 [endoplasmic reticulum membrane] (R-MMU-3006433) ITPR1 [platelet dense tubular network membrane] (R-MMU-3325593)	0.524	3
UniProt:P51572 BCAP31	5	BCAP31(238-246) [cytosol] (R-HSA-351912) BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587)	0.524	2
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.508	3
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.499	4
UniProt:Q9NYF8 BCLF1			0.499	2
UniProt:P63098 PPP3R1	2	PPP3R1 [cytosol] (R-HSA-51291) PPP3R1 [nucleoplasm] (R-HSA-2685631)	0.489	2
UniProt:P67775 PPP2CA	4	PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939)	0.488	2
UniProt:P28482 MAPK1	8	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853)	0.488	2
UniProt:Q9H2V7 SPNS1			0.463	2
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.463	6