Reactome | SLC25A5 [mitochondrial inner membrane]

SLC25A5 [mitochondrial inner membrane]

Stable Identifier

R-HSA-49743

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ADP/ATP translocase 2 monomer, ADP,ATP carrier protein, fibroblast isoform, adenine nucleotide translocator 2, ADP/ATP translocase 2, Adenine nucleotide translocator 2, ANT 2

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        Interactions of Vpr with host cellular proteins (Homo sapiens)
        
        Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization (Homo sapiens)
        
        Association of Vpr with ANT1 (Homo sapiens)
        
        ADP/ATP translocase monomer (generic) [mitochondrial inner membrane] (Homo sapiens)
        
        SLC25A5 [mitochondrial inner membrane] (Homo sapiens)
        
        ANT1:Vpr complex [mitochondrial inner membrane] (Homo sapiens)
        
        ADP/ATP translocase monomer (generic) [mitochondrial inner membrane] (Homo sapiens)
        
        SLC25A5 [mitochondrial inner membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12450408	The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae. Brandolin, G, Lauquin, GJ, Dianoux, AC, De Marcos Lousa, C, Trézéguet, V	Biochemistry	2002

External Reference Information

External Reference

UniProt:P05141 SLC25A5

Gene Names

SLC25A5, AAC2, ANT2

Chain

chain:1-298, initiator methionine:, chain:2-298

Reference Genes

BioGPS Gene:292 SLC25A5

COSMIC (genes):SLC25A5 SLC25A5

CTD Gene:292 SLC25A5

dbSNP Gene:292 SLC25A5

ENSEMBL:ENSG00000005022 SLC25A5

ENSEMBL_homo_sapiens_GENE:ENSG00000005022.6 SLC25A5

HGNC:10991 SLC25A5

KEGG Gene (Homo sapiens):292 SLC25A5

Monarch:292 SLC25A5

NCBI Gene:292 SLC25A5

OMIM:300150 SLC25A5

UCSC:P05141 SLC25A5

Reference Transcript

RefSeq:NM_001152.4 SLC25A5

Other Identifiers

11715399_at

11715400_x_at

17106574

200657_PM_at

200657_at

2547789

292

2996022

3002414

37740_r_at

3988831

3988832

3988837

3988838

3988839

3988840

3988842

3988844

3988845

3988846

3988847

3988848

8169640

A_23_P137057

A_23_P436179

A_24_P182182

A_24_P182183

GE57465

GO:0000295

GO:0002376

GO:0003723

GO:0005215

GO:0005471

GO:0005515

GO:0005634

GO:0005739

GO:0005743

GO:0005757

GO:0005856

GO:0005886

GO:0006914

GO:0007005

GO:0007059

GO:0008284

GO:0012501

GO:0015078

GO:0015207

GO:0015297

GO:0015853

GO:0016020

GO:0017077

GO:0023052

GO:0030154

GO:0030183

GO:0030218

GO:0031625

GO:0042645

GO:0043226

GO:0046902

GO:0048856

GO:0051503

GO:0055085

GO:0061024

GO:0071817

GO:0140021

GO:1901029

GO:1901526

GO:1902600

GO:1990544

GO:1990830

GO:1990845

HMNXSV003004676

ILMN_1774062

J02683_s_at

TC0X000586.hg

g4502098_3p_at

Participates

as a member of

as a component of

SLC25A5 dimer [mitochondrial inner membrane] (Homo sapiens)

Inferred To

slc25a5 [mitochondrial inner membrane] (Xenopus tropicalis)

Homologues of SLC25A5 [mitochondrial inner membrane] (Caenorhabditis elegans)

Homologues of SLC25A5 [mitochondrial inner membrane] (Danio rerio)

Homologues of SLC25A5 [mitochondrial inner membrane] (Drosophila melanogaster)

Homologues of SLC25A5 [mitochondrial inner membrane] (Plasmodium falciparum)

Homologues of SLC25A5 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

si:dkey-21o13.4 [mitochondrial inner membrane] (Danio rerio)

Ant2 [mitochondrial inner membrane] (Drosophila melanogaster)

SLC25A5 [mitochondrial inner membrane] (Bos taurus)

SLC25A5 [mitochondrial inner membrane] (Caenorhabditis elegans)

SLC25A5 [mitochondrial inner membrane] (Canis familiaris)

SLC25A5 [mitochondrial inner membrane] (Danio rerio)

SLC25A5 [mitochondrial inner membrane] (Dictyostelium discoideum)

SLC25A5 [mitochondrial inner membrane] (Drosophila melanogaster)

SLC25A5 [mitochondrial inner membrane] (Gallus gallus)

SLC25A5 [mitochondrial inner membrane] (Mus musculus)

SLC25A5 [mitochondrial inner membrane] (Plasmodium falciparum)

SLC25A5 [mitochondrial inner membrane] (Rattus norvegicus)

SLC25A5 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

SLC25A5 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

SLC25A5 [mitochondrial inner membrane] (Sus scrofa)

Cross References

RefSeq

NP_001143.2

Guide to Pharmacology - Targets

1063

OpenTargets

ENSG00000005022

HPA

ENSG00000005022-SLC25A5

GeneCards

P05141

Ensembl

ENST00000317881, ENSG00000005022, ENSP00000360671

PRO

P05141

Pharos - Targets

P05141

HMDB Protein

HMDBP03917

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.564	2
UniProt:Q96H96 COQ2	4	COQ2(1-371) [mitochondrial intermembrane space] (R-HSA-1267977) COQ2(1-34) [mitochondrial matrix] (R-HSA-8986157) COQ2(1-371) [mitochondrial inner membrane] (R-HSA-1299452) COQ2 [mitochondrial inner membrane] (R-HSA-1299439)	0.527	8
UniProt:P31040 SDHA	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.527	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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