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RIF1 [nucleoplasm]
Stable Identifier
R-HSA-480742
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Telomere-associated protein RIF1, RIF1_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
Activated ATM phosphorylates DCLRE1C (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
RIF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5UIP0 RIF1
Gene Names
RIF1
Chain
chain:1-2472
Reference Genes
BioGPS Gene:55183 RIF1
COSMIC (genes):RIF1 RIF1
CTD Gene:55183 RIF1
dbSNP Gene:55183 RIF1
ENSEMBL:ENSG00000080345 RIF1
ENSEMBL_homo_sapiens_GENE:ENSG00000080345.18 RIF1
HGNC:23207 RIF1
KEGG Gene (Homo sapiens):55183 RIF1
Monarch:55183 RIF1
NCBI Gene:55183 RIF1
OMIM:608952 RIF1
UCSC:Q5UIP0 RIF1
Reference Transcript
RefSeq:NM_001177665.1 RIF1
RefSeq:XM_005246665.3 RIF1
RefSeq:NM_001177664.1 RIF1
RefSeq:NM_018151.4 RIF1
RefSeq:NM_001177663.1 RIF1
Other Identifiers
11731683_a_at
11731684_at
11731685_s_at
11731686_x_at
11745224_a_at
11752738_a_at
11759068_at
16886503
214700_PM_x_at
214700_x_at
226503_PM_at
226503_at
226821_PM_at
226821_at
236620_PM_at
236620_at
240098_PM_at
240098_at
241820_PM_at
241820_at
2510486
2510487
2510488
2510489
2510490
2510492
2510493
2510494
2510495
2510499
2510501
2510502
2510504
2510506
2510507
2510508
2510509
2510510
2510511
2510514
2510517
2510519
2510520
2510523
2510524
2510525
2510527
2510529
2510530
2510531
2510533
2510534
2510535
2510536
2510537
2510538
2510539
2510540
2510541
2510542
2510543
2510545
2510546
2510547
2510548
2510549
2510550
2510551
2510552
2510553
2510554
2510555
2510556
2510557
2510558
2510559
2510560
2510561
2510562
2510563
2510564
32954_at
46563_at
53659_r_at
54867_at
55183
65415_s_at
78588_at
8045697
A_23_P382302
A_23_P5611
A_24_P34476
GE56515
GE80205
GE88669
GO:0000122
GO:0000723
GO:0000781
GO:0000785
GO:0000793
GO:0001939
GO:0001940
GO:0002376
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005819
GO:0005856
GO:0005886
GO:0006281
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006974
GO:0007049
GO:0031509
GO:0031965
GO:0032200
GO:0035019
GO:0035861
GO:0043226
GO:0043247
GO:0045814
GO:0045830
GO:0048856
GO:0051233
GO:0140445
GO:1990830
GO:2000042
GO:2001034
HMNXSV003021923
Hs.134724.0.A1_3p_at
Hs.19150.0.S1_3p_at
Hs.225841.0.S1_3p_at
Hs.225841.1.S1_3p_a_at
Hs.254020.0.A1_3p_at
Hs.254020.1.S1_3p_at
ILMN_1755758
ILMN_2149053
PH_hs_0040594
TC02000939.hg
TC02003637.hg
U79263_at
Participates
as an output of
Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)
as a component of
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
as an input of
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
Inferred To
rif1 [nucleoplasm]
(Schizosaccharomyces pombe)
rif1 [nucleoplasm]
(Xenopus tropicalis)
RIF1 [nucleoplasm]
(Bos taurus)
RIF1 [nucleoplasm]
(Canis familiaris)
RIF1 [nucleoplasm]
(Dictyostelium discoideum)
RIF1 [nucleoplasm]
(Gallus gallus)
RIF1 [nucleoplasm]
(Saccharomyces cerevisiae)
RIF1 [nucleoplasm]
(Sus scrofa)
Rif1 [nucleoplasm]
(Drosophila melanogaster)
Rif1 [nucleoplasm]
(Mus musculus)
Rif1 [nucleoplasm]
(Rattus norvegicus)
rif-1.1 [nucleoplasm]
(Caenorhabditis elegans)
fc38c03 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
XP_005246722.1
,
NP_060621.3
,
NP_001171136.1
,
NP_001171134.1
,
NP_001171135.1
OpenTargets
ENSG00000080345
GeneCards
Q5UIP0
HPA
ENSG00000080345-RIF1
Ensembl
ENST00000243326
,
ENSP00000390181
,
ENST00000444746
,
ENSP00000414615
,
ENST00000430328
,
ENST00000453091
,
ENST00000428287
,
ENSP00000416123
,
ENSP00000243326
,
ENSP00000415691
,
ENSG00000080345
PRO
Q5UIP0
Pharos - Targets
Q5UIP0
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.758
5
UniProt:P62140 PPP1CB
4
PPP1CB [cytosol]
(R-HSA-163405)
PPP1CB P49R [cytosol]
(R-HSA-9660547)
PPP1CB A56P [cytosol]
(R-HSA-9660543)
PPP1CB [nucleoplasm]
(R-HSA-62003)
0.676
4
UniProt:P54132 BLM
2
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
BLM [nucleoplasm]
(R-HSA-174881)
0.667
7
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.569
3
UniProt:P36873-1 PPP1CC
0.547
2
UniProt:P15927 RPA2
2
RPA2 [nucleoplasm]
(R-HSA-68457)
p-S33-RPA2 [nucleoplasm]
(R-HSA-5685148)
0.547
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q15435 PP1R7
0.508
2
UniProt:Q9H9A7 RMI1
1
RMI1 [nucleoplasm]
(R-HSA-5685949)
0.462
4
UniProt:Q13472 TOP3A
1
TOP3A [nucleoplasm]
(R-HSA-912452)
0.462
3
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