Reactome | KAT6A [nucleoplasm]

KAT6A [nucleoplasm]

Stable Identifier

R-HSA-480310

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone acetyltransferase MYST3, MYST3, MYST3_HUMAN

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        AKT phosphorylates KAT6A (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)
        
        KAT6A acetylates TP53 (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)
        
        MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
        
        BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        KAT6A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92794 KAT6A

Gene Names

KAT6A, MOZ, MYST3, RUNXBP2, ZNF220

Chain

chain:1-2004

Reference Genes

BioGPS Gene:7994 KAT6A

COSMIC (genes):KAT6A KAT6A

CTD Gene:7994 KAT6A

dbSNP Gene:7994 KAT6A

ENSEMBL:ENSG00000083168 KAT6A

ENSEMBL_homo_sapiens_GENE:ENSG00000083168.11 KAT6A

HGNC:13013 KAT6A

KEGG Gene (Homo sapiens):7994 KAT6A

Monarch:7994 KAT6A

NCBI Gene:7994 KAT6A

OMIM:601408 KAT6A

UCSC:Q92794 KAT6A

Reference Transcript

Other Identifiers

11726634_a_at

11726635_a_at

11726636_s_at

11740237_a_at

17076694

202423_PM_at

202423_at

216361_PM_s_at

216361_s_at

226547_PM_at

226547_at

2918177

3133136

3133137

3133138

3133139

3133140

3133141

3133142

3133143

3133144

3133146

3133148

3133149

3133150

3133151

3133152

3133153

3133154

3133159

3133160

3133161

3133162

3133163

3133164

3133165

3133170

3133171

3133172

3133173

3133174

3133175

3133176

38377_at

55638_at

7994

8150491

840_at

A_23_P407628

A_33_P3287735

GE59192

GO:0000123

GO:0000786

GO:0002376

GO:0003677

GO:0003712

GO:0003713

GO:0003824

GO:0004402

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005829

GO:0006325

GO:0006334

GO:0006351

GO:0006355

GO:0006473

GO:0008270

GO:0010628

GO:0016407

GO:0016573

GO:0016605

GO:0016607

GO:0016740

GO:0016746

GO:0023052

GO:0030099

GO:0030154

GO:0036211

GO:0036408

GO:0043226

GO:0043995

GO:0043996

GO:0043997

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0046972

GO:0048856

GO:0050793

GO:0051276

GO:0061733

GO:0065003

GO:0070776

GO:0090398

GO:0140096

GO:0140110

GO:0140297

GO:1901796

GO:1903706

HMNXSV003047831

Hs.93231.0.A1_3p_at

Hs.93231.0.A1_3p_x_at

ILMN_2095840

PH_hs_0022213

PH_hs_0031413

TC08001173.hg

U47742_at

g5803097_3p_at

Participates

as a member of

KAT6A,B [nucleoplasm] (Homo sapiens)

as a component of

KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

KAT6A (1-1118) [nucleoplasm]

p-T369-KAT6A [nucleoplasm]

Inferred To

Homologues of KAT6A [nucleoplasm] (Dictyostelium discoideum)

mys-4 [nucleoplasm] (Caenorhabditis elegans)

myst3 [nucleoplasm] (Danio rerio)

enok [nucleoplasm] (Drosophila melanogaster)

KAT6A [nucleoplasm] (Bos taurus)

KAT6A [nucleoplasm] (Canis familiaris)

KAT6A [nucleoplasm] (Dictyostelium discoideum)

KAT6A [nucleoplasm] (Gallus gallus)

KAT6A [nucleoplasm] (Mus musculus)

KAT6A [nucleoplasm] (Rattus norvegicus)

KAT6A [nucleoplasm] (Schizosaccharomyces pombe)

KAT6A [nucleoplasm] (Sus scrofa)

kat6a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_016869353.1, NP_006757.2, XP_016869352.1

Guide to Pharmacology - Targets

2665

OpenTargets

ENSG00000083168

GeneCards

Q92794

HPA

ENSG00000083168-KAT6A

Ensembl

ENSG00000083168, ENSP00000265713, ENST00000265713, ENST00000396930, ENSP00000380136

PRO

Q92794

Pharos - Targets

Q92794

Orphanet

22564

HMDB Protein

HMDBP11800

PDB

7Y43, 6LSB, 5B77, 8H7A, 8DD5, 4LK9, 5B76, 2RC4, 5B75, 2OZU, 2LN0, 4LLB, 4LJN, 4LKA, 3V43, 1M36, 5B78

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03164-PRO_0000390950 KMT2A			0.556	10
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.556	4