SUMOylation of NR1I2 with SUMO3

Stable Identifier
R-HSA-4755524
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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NR1I2 (Pregnane X Receptor, PXR) is SUMOylated with SUMO3 (Hu et al. 2010). SUMOylation is stimulated when NR1I2 binds ligand (rifampicin) and causes NR1I2 to transrepress genes encoding inflammatory cytokines.

Literature References
PubMed ID Title Journal Year
20719936 Pregnane X receptor is SUMOylated to repress the inflammatory response

Hu, G, Xu, C, Staudinger, JL

J. Pharmacol. Exp. Ther. 2010
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