SUMOylation of NR1H4 with SUMO1

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NR1H4 (FXR, Bile Acid Receptor) is SUMOylated with SUMO1 at lysine-132 and lysine-289 (lysine-122 and lysine-275 of isoform 4, UniProt Q96RI1-2) (Vavassori et al. 2009, Balasubramaniyan et al. 2013). SUMOylation appears to be enhanced when NR1H4 binds ligands (Vavassori et al. 2009). SUMOylated NR1H4 transrepresses genes involved in inflammation (Vavassori et al. 2009) and inhibits ligand-induced activation of FXR targets: bile salt export pump (BSEP) and small heterodimer partner (SHP) (Balasubramaniya et al. 2013).

Literature References
PubMed ID Title Journal Year
19864602 The bile acid receptor FXR is a modulator of intestinal innate immunity

Vavassori, P, Mencarelli, A, Renga, B, Distrutti, E, Fiorucci, S

J. Immunol. 2009
23546875 SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes

Balasubramaniyan, N, Luo, Y, Sun, AQ, Suchy, FJ

J. Biol. Chem. 2013
Participant Of
Orthologous Events