PIAS4 SUMOylates IKBKG with SUMO1

Stable Identifier
R-HSA-4755411
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS4 SUMOylates IKBKG with SUMO1 at lysine-277 and lysine-309 (Huang et al. 2003, Mabb et al. 2006). SUMOylation occurs in the nucleus when IKBKG is unbound to IKK. The interaction between PIAS4 and IKBKG is increased by genotoxic stress. SUMOylation is independent of ATM.

Literature References
PubMed ID Title Journal Year
14651848 Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

Huang, TT, Wuerzberger-Davis, SM, Wu, ZH, Miyamoto, S

Cell 2003
16906147 PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress

Mabb, AM, Wuerzberger-Davis, SM, Miyamoto, S

Nat. Cell Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created