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KDM6A [nucleoplasm]
Stable Identifier
R-HSA-4754224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lysine-specific demethylase 6A ecNumber1.14.11.-/ecNumber, KDM6A_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA2 chromatin is activated (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA2 gene is transcribed (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA3 chromatin is activated (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA3 gene is transcribed (Homo sapiens)
MAFB, HOXB1:PBX1:PKNOX1 at active HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXA2 expression (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXB2 expression (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 chromatin is activated (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 gene is transcribed (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB3 chromatin is activated (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB3 gene is transcribed (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXC4 chromatin is activated (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXC4 gene is transcribed (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXD4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB, HOXB1:PBX1:PKNOX1 at active HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15550 KDM6A
Gene Names
KDM6A, UTX
Chain
chain:1-1401
Reference Genes
BioGPS Gene:7403 KDM6A
COSMIC (genes):KDM6A KDM6A
CTD Gene:7403 KDM6A
dbSNP Gene:7403 KDM6A
ENSEMBL:ENSG00000147050 KDM6A
HGNC:12637 KDM6A
KEGG Gene (Homo sapiens):7403 KDM6A
Monarch:7403 KDM6A
NCBI Gene:7403 KDM6A
OMIM:300128 KDM6A
UCSC:O15550 KDM6A
Reference Transcript
RefSeq:NM_021140.3 KDM6A
Other Identifiers
0000610086
1165
11743085_a_at
11749091_a_at
17102861
203990_s_at
203991_s_at
203992_s_at
2111
39703_at
3975471
3975472
3975473
3975475
3975487
3975490
3975496
3975499
3975503
3975504
3975505
3975506
3975508
3975509
3975510
3975511
3975513
3975514
3975515
3975516
3975517
3975518
3975519
3975520
3975521
3975522
3975524
3975525
3975526
3975527
3975528
3975529
3975533
3975534
3975539
3975541
3975543
3975544
3975545
3975546
3975547
3975548
3975549
3AVR
3AVS
4035037
4035043
4035058
4035072
4035091
568
6FUK
6FUL
7403
8166956
A0A087WUN6
A0A087X0R0
A_14_P116222
A_23_P217304
A_33_P3218955
A_33_P3340718
AAC51839
AAC51840
AAH93868
AAI13382
AC136488
AF000992
AF000993
AL133545
AL138744
BC093868
BC113381
CCDS14265
CH471141
EAW59368
ENSG00000147050
ENSP00000367203
ENSP00000405910
ENST00000377967
ENST00000377967.8
ENST00000414389
EntrezGene:7403
EntrezGene:KDM6A
F5H5V6
F5H6S1
F8W8R6
g10863942_3p_a_at
g2580569_3p_a_at
GE54033
GO:0000228
GO:0000790
GO:0000978
GO:0001701
GO:0001843
GO:0003007
GO:0003016
GO:0003674
GO:0003677
GO:0003682
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006338
GO:0006464
GO:0007165
GO:0007267
GO:0007507
GO:0008150
GO:0009790
GO:0010468
GO:0010628
GO:0016491
GO:0021915
GO:0030154
GO:0031490
GO:0032525
GO:0032991
GO:0035097
GO:0035264
GO:0040007
GO:0042802
GO:0043167
GO:0043226
GO:0043565
GO:0044666
GO:0046872
GO:0048333
GO:0048568
GO:0048570
GO:0048646
GO:0048856
GO:0051213
GO:0051276
GO:0051568
GO:0055114
GO:0060070
GO:0071557
GO:0071558
GO:0072358
HGNC:12637
HPA000568
HPA001165
HPA002111
Hs.13980.0.S1_3p_a_at
Hs.13980.0.S1_3p_s_at
ILMN_1654488
IPR003347
IPR011990
IPR013026
IPR019734
KDM6A
KDM6A-201
LRG_616
LRG_616t1
MIM:147920
MIM:300128
MIM:300867
NM_021140
NP_066963
PF02373
PF13181
PF13432
PH_hs_0022992
SM00028
SM00558
TC0X000212.hg
UPI000013DA92
XM_005272659
XM_011543964
XM_011543970
XM_011543974
XP_005272716
XP_011542266
XP_011542272
XP_011542276
Participant Of
hasComponent
MLL2,3 complex [nucleoplasm]
hasMember
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm]
Inferred To
KDM6A [nucleoplasm] (Bos taurus)
KDM6A [nucleoplasm] (Caenorhabditis elegans)
KDM6A [nucleoplasm] (Canis familiaris)
KDM6A [nucleoplasm] (Dictyostelium discoideum)
KDM6A [nucleoplasm] (Rattus norvegicus)
KDM6A [nucleoplasm] (Sus scrofa)
Homologues of KDM6A [nucleoplasm] (Caenorhabditis elegans)
Kdm6a [nucleoplasm] (Mus musculus)
Cross References
RefSeq
NP_066963.2
OpenTargets
ENSG00000147050
GeneCards
O15550
ZINC target
O15550
PRO
O15550
Orphanet
20781
PDB
3AVR
,
3AVS
,
6FUK
,
6FUL
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.527
5
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.527
4
UniProt:Q6ZW49 PAXIP1
1
PAXIP1 [nucleoplasm]
(R-HSA-5619395)
0.527
7
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.462
4
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