HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3

Stable Identifier
R-HSA-4720432
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

HDAC4 SUMOylates NR1H2 (LXR-beta) with SUMO2,3 at lysine-409 and lysine-447 (lysine-410 and lysine-448 of the isoform used by Ghisletti et al. 2007) (Venteclef et al. 2010). SUMOylation is enhanced when NR1H2 binds specific oxysterols and causes NR1H2 to recruit the NCOR repressor and transrepress promoters such as iNOS.

Literature References
PubMed ID Title Journal Year
17218271 Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

Ghisletti, S, Huang, W, Ogawa, S, Pascual, G, Lin, ME, Willson, TM, Rosenfeld, MG, Glass, CK

Mol. Cell 2007
20159957 GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

Venteclef, N, Jakobsson, T, Ehrlund, A, Damdimopoulos, A, Mikkonen, L, Ellis, E, Nilsson, LM, Parini, P, Jänne, OA, Gustafsson, JA, Steffensen, KR, Treuter, E

Genes Dev. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of HDAC4 [nucleoplasm]
Physical Entity
HDAC4 [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Canis familiaris)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Danio rerio)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Mus musculus)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Rattus norvegicus)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Sus scrofa)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-10-19)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-20)