HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3

Stable Identifier
R-HSA-4720432
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HDAC4 SUMOylates NR1H2 (LXR-beta) with SUMO2,3 at lysine-409 and lysine-447 (lysine-410 and lysine-448 of the isoform used by Ghisletti et al. 2007) (Venteclef et al. 2010). SUMOylation is enhanced when NR1H2 binds specific oxysterols and causes NR1H2 to recruit the NCOR repressor and transrepress promoters such as iNOS.

Literature References
PubMed ID Title Journal Year
17218271 Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

Ghisletti, S, Huang, W, Ogawa, S, Pascual, G, Lin, ME, Willson, TM, Rosenfeld, MG, Glass, CK

Mol. Cell 2007
20159957 GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

Venteclef, N, Jakobsson, T, Ehrlund, A, Damdimopoulos, A, Mikkonen, L, Ellis, E, Nilsson, LM, Parini, P, Jänne, OA, Gustafsson, JA, Steffensen, KR, Treuter, E

Genes Dev. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of HDAC4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created