PIAS1 SUMOylates THRB with SUMO3

Stable Identifier
R-HSA-4719448
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1 SUMOylates THRB with SUMO3 at lysine-50, lysine-146, and lysine-443 (Liu et al. 2012). SUMOylation is required for induction of transcription in response to ligand binding.

Literature References
PubMed ID Title Journal Year
22930759 Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation

Liu, YY, Kogai, T, Schultz, JJ, Mody, K, Brent, GA

J. Biol. Chem. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created