PIAS2-2 SUMOylates THRA with SUMO1

Stable Identifier
R-HSA-4719447
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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PIAS2-2 SUMOylates THRA with SUMO1
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PIAS2-2 (PIASx-alpha) SUMOylates THRA (alpha-1 isoform) with SUMO1 at lysine-283 and lysine-389 (Liu et al. 2012). (A lysine residue corresponding to lysine-389 does not exist in the alpha-2 isoform.) SUMOylation by SUMO3 but not SUMO1 enhances induction of gene expression in response to the ligand triiodothyroxine.

Literature References
PubMed ID Title Journal Year
22930759 Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation

Liu, YY, Kogai, T, Schultz, JJ, Mody, K, Brent, GA

J. Biol. Chem. 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS2-2 [nucleoplasm]
Physical Entity
PIAS2-2 [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
PIAS2-2 SUMOylates THRA with SUMO1 (Bos taurus)
PIAS2-2 SUMOylates THRA with SUMO1 (Caenorhabditis elegans)
PIAS2-2 SUMOylates THRA with SUMO1 (Canis familiaris)
PIAS2-2 SUMOylates THRA with SUMO1 (Danio rerio)
PIAS2-2 SUMOylates THRA with SUMO1 (Gallus gallus)
PIAS2-2 SUMOylates THRA with SUMO1 (Mus musculus)
PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)
PIAS2-2 SUMOylates THRA with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-10-18)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-19)