PIAS1,2-2 SUMOylate PPARG with SUMO1

Stable Identifier
R-HSA-4717461
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from mouse homologs, PIAS1,2-2 SUMOylate PPARG with SUMO1 at lysine-107 and lysine-395 (lysine-77 and lysine-365 of the shorter variant 1). SUMOylation decreases the transcriptional activation activity of PPARG. SUMOylation at lysine-395 is ligand-dependent and causes PPARG to recruit corepressors such as NCOR and HDAC3.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,2-2 [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created