CBX4 (Pc2) SUMOylates DNMT3A with SUMO1

Stable Identifier
R-HSA-4655440
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As inferred from mouse homologs, CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 at more than one lysine residue in the N-terminal (regulatory) domain. SUMOylation reduces the interaction of DNMT3A with HDAC1 and HDAC2.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created