Reactome | AES [nucleoplasm]

AES [nucleoplasm]

Stable Identifier

R-HSA-4648963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

GRG

Locations in the PathwayBrowser for interactor UniProt:Q9NYB9 ABI2

Expand all

External Reference Information

External Reference

UniProt:Q08117 TLE5

Gene Names

TLE5, AES, GRG, GRG5

Chain

chain:1-197

Reference Genes

BioGPS Gene:166 TLE5

CTD Gene:166 TLE5

dbSNP Gene:166 TLE5

ENSEMBL:ENSG00000104964 AES

HGNC:307 TLE5

KEGG Gene (Homo sapiens):166 TLE5

Monarch:166 TLE5

NCBI Gene:166 TLE5

OMIM:600188 TLE5

UCSC:Q08117 TLE5

Reference Transcript

Other Identifiers

0000380398

0006860286

11739314_x_at

11745774_x_at

11753031_x_at

166

16867047

217729_3p_s_at

217729_s_at

3846115

3846116

3846117

3846118

3846119

3846120

3846121

3846122

3846124

3846126

3846128

3846131

3846135

3846139

3846140

3846141

3846142

3846143

41337_at

41338_at

49499

76050_s_at

8032576

A_23_P165061

A_23_P341312

AAA16223

AAC35517

AAC72103

AAD00654

AAI13736

AAI13738

AC005944

AES

AF072902

AK094591

AK314713

BAG37257

BAG52894

BC113735

BC113737

CAA51768

CCDS12101

CCDS12102

CH471139

EAW69345

EAW69347

ENSG00000104964

ENSP00000221561

ENSP00000317537

ENST00000221561

ENST00000221561.12

ENST00000327141

ENST00000327141.8

EntrezGene:166

EntrezGene:TLE5

g6382065_3p_s_at

g6382065_3p_x_at

GE80148

GO:0000122

GO:0001501

GO:0003674

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005667

GO:0006355

GO:0006357

GO:0007165

GO:0007267

GO:0007275

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0009887

GO:0010629

GO:0016055

GO:0031668

GO:0032091

GO:0032991

GO:0034641

GO:0040007

GO:0040008

GO:0043226

GO:0045892

GO:0048856

GO:0060761

GO:0070491

GO:0070555

GO:0090090

GO:2000210

HGNC:307

HPA049499

ILMN_1707958

ILMN_1712944

ILMN_2333107

IPR005617

IPR009146

K7ELQ8

K7EQH5

MIM:600188

NM_001130

NM_198969

NM_198970

NP_001121

NP_945320

NP_945321

PF03920

PH_hs_0026114

TC19001041.hg

TC19002293.hg

TLE5

TLE5-201

TLE5-202

U04241

U04241_at

U88831

U88832

UPI0000043C26

UPI00001AE637

X73358

X73358_s_at

XM_006722664

XP_006722727

Participant Of

hasComponent

TLE:AES [nucleoplasm]

input

TLE forms non-functional complexes with AES

Cross References

RefSeq

NP_945321.1, NP_001121.2, NP_945320.1

OpenTargets

ENSG00000104964

GeneCards

Q08117

PRO

Q08117

Interactors (118)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3E5 PTRH2	2	PolyUb-PTRH2 [mitochondrial outer membrane] (R-HSA-6783190) PTRH2 [mitochondrial outer membrane] (R-HSA-5696909)	0.69	7
UniProt:Q9H5Z6 F124B			0.556	3
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [specific granule lumen] (R-HSA-6799553) CRACR2A [extracellular region] (R-HSA-6806289)	0.556	3
UniProt:Q8N5A5-2 ZGPAT			0.556	3
UniProt:Q9UFD9 RIM3A			0.556	3
UniProt:P98175 RBM10			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q8IYR0 CF206			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q96FQ7 CR018			0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.556	3
UniProt:P61968 LMO4			0.556	3
UniProt:Q9Y333 LSM2	2	LSM2 [cytosol] (R-HSA-429849) LSM2 [nucleoplasm] (R-HSA-71894)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:P79522 PRR3			0.556	3
UniProt:Q96A72 MAGOHB	1	MAGOHB [nucleoplasm] (R-HSA-8867888)	0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q5TAL4 Q5TAL4			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q9BQY4 RHXF2			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q9H614 Q9H614			0.556	3
UniProt:Q8N5A5 ZGPAT			0.556	3
UniProt:Q86VM6 Q86VM6			0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:Q9H609 ZN576			0.556	3
UniProt:Q86V42 F124A			0.556	3
UniProt:Q9UBB6 NCDN			0.556	3
UniProt:Q9HBI0 PARVG			0.556	3
UniProt:Q15014 MORF4L2	1	MORF4L2 [nucleoplasm] (R-HSA-3322945)	0.556	3
UniProt:O15409 FOXP2			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q96CA5 BIRC7			0.556	3
UniProt:F6RF56 F6RF56			0.556	3
UniProt:Q14689-6 DIP2A			0.556	3
UniProt:Q13131 PRKAA1	3	PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206) p-T183-PRKAA1 [cytosol] (R-HSA-380964)	0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:P35711 SOX5			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:O15119 TBX3			0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q9NX04 CA109			0.556	3
UniProt:Q04864 REL	2	REL [nucleoplasm] (R-HSA-1168585) REL [cytosol] (R-HSA-1168579)	0.556	3
UniProt:Q9BRQ3 NUD22			0.556	3
UniProt:P47897-2 QARS			0.556	3
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.556	3
UniProt:Q15475 SIX1			0.556	3
UniProt:P78362 SRPK2			0.556	3
UniProt:O75069-4 TMCC2			0.556	3
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.556	3
UniProt:Q9HC98 NEK6	2	p-S206-NEK6 [cytosol] (R-HSA-2984253) NEK6 [cytosol] (R-HSA-2530596)	0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:Q12899 TRIM26	1	TRIM26 [cytosol] (R-HSA-5624324)	0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.556	3
UniProt:Q8WTP8 AEN			0.556	3
UniProt:Q96PN8 TSSK3			0.556	3
UniProt:Q5T124 UBX11			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q96Q77 CIB3			0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q8IV54 Q8IV54			0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [extracellular region] (R-HSA-2396419)	0.556	3
UniProt:Q9UJX0 OSGI1			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q8N684 CPSF7	1	CPSF7 [nucleoplasm] (R-HSA-72012)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q96EP0-3 RNF31			0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:O95751 LDOC1			0.556	3
UniProt:Q9BZW7 TSG10			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q7RTU3 OLIG3			0.556	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:O43559 FRS3	3	FRS3 [plasma membrane] (R-HSA-191482) p-5Y-FRS3 [plasma membrane] (R-HSA-191475) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:P54646 PRKAA2	4	p-T172-PRKAA2 [cytosol] (R-HSA-200417) PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q9UH92 MLX	1	MLX [nucleoplasm] (R-HSA-163695)	0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) p-T231-CARD9 [plasma membrane] (R-HSA-5607623) CARD9 [plasma membrane] (R-HSA-5607662)	0.556	3
UniProt:P47897 QARS	2	QARS [mitochondrial matrix] (R-HSA-379592) QARS [cytosol] (R-HSA-379615)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.556	5
UniProt:O75909 CCNK	1	CCNK [nucleoplasm] (R-HSA-6796619)	0.556	3
UniProt:P14136 GFAP	3	GFAP [lysosomal membrane] (R-HSA-9625195) p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P84022 SMAD3	12	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 S425F [cytosol] (R-HSA-8944158) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) SMAD3 [nucleoplasm] (R-HSA-206150) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 S425C [cytosol] (R-HSA-3308499)	0.556	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.556	3
UniProt:P26368 U2AF2	1	U2AF2 [nucleoplasm] (R-HSA-71987)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q969R5 L3MBTL2	2	SUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480) L3MBTL2 [nucleoplasm] (R-HSA-6804477)	0.556	3
UniProt:O43167 ZBT24			0.556	3
UniProt:Q8TES7-6 FBF1			0.556	3
UniProt:Q15742 NAB2			0.556	3
UniProt:O75360 PROP1			0.508	4