SUMOylation of TOP2B with SUMO1

Stable Identifier
R-HSA-4641345
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SUMOylation of TOP2B with SUMO1
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TOP2B is SUMOylated with SUMO1 (Mao et al. 2000, Isik et al. 2003). SUMOylation is observed in response to topoisomerase-mediated DNA damage induced by teniposide.

Literature References
PubMed ID Title Journal Year
12832072 The SUMO pathway is required for selective degradation of DNA topoisomerase IIbeta induced by a catalytic inhibitor ICRF-193(1)

Isik, S, Sano, K, Tsutsui, K, Seki, M, Enomoto, T, Saitoh, H, Tsutsui, K

FEBS Lett. 2003
10862613 SUMO-1 conjugation to human DNA topoisomerase II isozymes

Mao, Y, Desai, SD, Liu, LF

J. Biol. Chem. 2000
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
protein sumoylation (0016925)
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
SUMO1:C93-UBE2I [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
SUMOylation of TOP2B with SUMO1 (Bos taurus)
SUMOylation of TOP2B with SUMO1 (Caenorhabditis elegans)
SUMOylation of TOP2B with SUMO1 (Canis familiaris)
SUMOylation of TOP2B with SUMO1 (Danio rerio)
SUMOylation of TOP2B with SUMO1 (Dictyostelium discoideum)
SUMOylation of TOP2B with SUMO1 (Mus musculus)
SUMOylation of TOP2B with SUMO1 (Plasmodium falciparum)
SUMOylation of TOP2B with SUMO1 (Saccharomyces cerevisiae)
SUMOylation of TOP2B with SUMO1 (Schizosaccharomyces pombe)
SUMOylation of TOP2B with SUMO1 (Sus scrofa)
SUMOylation of TOP2B with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-09-27)
Reviewed
Zhang, XD  (2015-10-04)
Created
May, B  (2013-09-28)