Reactome | TLE recruits HDAC1 to WNT promoters

TLE recruits HDAC1 to WNT promoters

Stable Identifier

R-HSA-4641231

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Groucho/TLE mediates repression of WNT target genes in part by recruiting a histone deacetlyase to the promoter. The weakly conserved central GP domain of Groucho/TLE has been shown to interact with the histone deacetylase RPD3/HDAC1 (Brantjes et al, 2001; Chen et al, 1999). Knockdown of rpd3 in Drosophila cells, or treatment of human or Drosophila cells with the histone deacetylase inhibitor Trichostatin A significantly decreases repression of a Groucho/TLE dependent reporter gene, and Groucho and RPD3 have been shown to co-localize to chromatin of target genes by ChIP leading to deacetylation of H3K9, H3K14, K4K5, H4K8 and H4K12 (Chen et al, 1999; Choi et al 1999; Winkler et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
10559189	The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription Kim, Y, Choi, CY, Kwon, HJ, Kim, YH	J. Biol. Chem.	1999
20405012	Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density Ponce, A, Courey, AJ, Winkler, CJ	PLoS ONE	2010
11266540	All Tcf HMG box transcription factors interact with Groucho-related co-repressors van De Wetering, M, Clevers, HC, Brantjes, H, Roose, J	Nucleic Acids Res.	2001
10485845	A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development Chen, G, Mische, S, Fernandez, J, Courey, AJ	Genes Dev.	1999