SMURF2 binds AXIN

Stable Identifier
R-HSA-4641134
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SMURF2 is an E3 ubiquitin ligase for AXIN and promotes its ubiquitin-mediated degradation. Ectopic SMURF2 immunoprecipitates both exogenously expressed and endogenous AXIN. AXIN is polyubiquitinated by SMURF2 at lysine 505 both in vitro and in vivo (Kim and Jho, 2012).

Literature References
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