SUMOylation of HDAC2 with SUMO1

Stable Identifier
R-HSA-4616015
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HDAC2 is SUMOylated at lysine-462 with SUMO1 (Brandl et al. 2012). SUMOylation of HDAC2 blocks TP53-dependent (p53-dependent) expression of genes but is required for induction of NF-kB-dependent gene expression (Wagner et al. 2015).

Literature References
PubMed ID Title Journal Year
25704882 Sumoylation of HDAC2 promotes NF-κB-dependent gene expression

Wagner, T, Kiweler, N, Wolff, K, Knauer, SK, Brandl, A, Hemmerich, P, Dannenberg, JH, Heinzel, T, Schneider, G, Krämer, OH

Oncotarget 2015
22493095 Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

Brandl, A, Wagner, T, Uhlig, KM, Knauer, SK, Stauber, RH, Melchior, F, Schneider, G, Heinzel, T, Krämer, OH

J Mol Cell Biol 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created