PIAS2-2 SUMOylates SUZ12 with SUMO1

Stable Identifier
R-HSA-4615873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS2-2 (PIASxbeta) SUMOylates SUZ12, a subunit of the Polycomb Repressive Complex 2 (PRC2), at lysine-75 with SUMO1 (Riising et al. 2008). SUMOyation does not affect the repression of transcription by PRC2. The effect of SUMOylation on PRC2 function is unknown. The EZH2 subunit of PRC2 can also be SUMOylated at multiple positions.

Literature References
PubMed ID Title Journal Year
18628979 The polycomb repressive complex 2 is a potential target of SUMO modifications

Riising, EM, Boggio, R, Chiocca, S, Helin, K, Pasini, D

PLoS ONE 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS2-2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created