SUMOylation of XPC with SUMO1

Stable Identifier
R-HSA-4570528
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

XPC is SUMOylated at lysine-655 with SUMO1 (Wang et al. 2005, 2007). SUMOylation occurs after UV irradiation and may target XPC for destruction (Wang et al. 2007).

Literature References
PubMed ID Title Journal Year
17693435 Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair

Wang, QE, Praetorius-Ibba, M, Zhu, Q, El-Mahdy, MA, Wani, G, Zhao, Q, Qin, S, Patnaik, S, Wani, AA

Nucleic Acids Res. 2007
16030353 DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation

Wang, QE, Zhu, Q, Wani, G, El-Mahdy, MA, Li, J, Wani, AA

Nucleic Acids Res. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created