PIAS1,2-1 SUMOylates XRCC4 with SUMO1

Stable Identifier
R-HSA-4568848
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1,2-1 SUMOylate XRCC4 at lysine-210 with SUMO1 (Yurchenko et al. 2006). SUMOylation causes localization of XRCC4 to the nucleus. (An unSUMOylatable mutant of XRCC4 is localized to the cytosol.)

Literature References
PubMed ID Title Journal Year
16478998 SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair

Yurchenko, V, Xue, Z, Sadofsky, MJ

Mol. Cell. Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,2-1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created