CDKN2A (p14-ARF) SUMOylates WRN with SUMO1

Stable Identifier
R-HSA-4568846
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CDKN2A (p14-ARF) SUMOylates WRN at lysine-356, lysine-496, and lysine-898 with SUMO1 (Woods et al. 2004). SUMOylation of WRN causes it to be released from the nucleolus.

Literature References
PubMed ID Title Journal Year
15355988 p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Woods, YL, Xirodimas, DP, Prescott, AR, Sparks, A, Lane, DP, Saville, MK

J. Biol. Chem. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of p14ARF [nucleoplasm]
Physical Entity
Activity
Authored
Reviewed
Created