CBX4 SUMOylates CBX4 in PRC1 with SUMO1

Stable Identifier
R-HSA-4551727
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CBX4 in Polycomb Repressive Complex 1 (PRC1) autoSUMOylates with SUMO1 (Kagey et al.2005, Roscic et al. 2006, Merrill et al. 2010). As inferred from mouse homologs, SUMOylation of CBX4 appears to be essential for recruitment of the PRC1 complex to histone H3 trimethylated at lysine-27 (H3K27me3) (Kang et al. 2010).

Literature References
PubMed ID Title Journal Year
15592428 Multiple activities contribute to Pc2 E3 function

Kagey, MH, Melhuish, TA, Powers, SE, Wotton, D

EMBO J. 2005
17018294 Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2

Roscic, A, Möller, A, Calzado, MA, Renner, F, Wimmer, VC, Gresko, E, Lüdi, KS, Schmitz, ML

Mol. Cell 2006
20098713 A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity

Merrill, JC, Melhuish, TA, Kagey, MH, Yang, SH, Sharrocks, AD, Wotton, D

PLoS ONE 2010
20417598 SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development

Kang, X, Qi, Y, Zuo, Y, Wang, Q, Zou, Y, Schwartz, RJ, Cheng, J, Yeh, ET

Mol. Cell 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created