CBX4 SUMOylates BMI1 in PRC1 with SUMO1

Stable Identifier
R-HSA-4551655
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CBX4 SUMOylates BMI1 in Polycomb Repressive Complex 1 (PRC1) at lysine-88 (Ismail et al. 2012). SUMOylation of BMI1 is necessary for its accumulation at sites of DNA damage. CBX4 directly binds poly(ADP-ribose) synthesized by PARP1 at sites of damage.

Literature References
PubMed ID Title Journal Year
22402492 CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage

Ismail, IH, Gagné, JP, Caron, MC, McDonald, D, Xu, Z, Masson, JY, Poirier, GG, Hendzel, MJ

Nucleic Acids Res. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created