RANBP2 SUMOylates RANBP2 with SUMO1

Stable Identifier
R-HSA-4551649
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RANBP2 SUMOylates RANBP2 at lysine-2592, lysine-2650, and lysine-2723 with SUMO1 (Pichler et al. 2002, Pichler et al. 2004, Cooper et al. 2005). RANBP2 does not resemble HECT or RING type SUMO E3 ligases and instead uses hydrophobic interactions with UBE2I (UBC9) to catalyze SUMOylation.

Literature References
PubMed ID Title Journal Year
11792325 The nucleoporin RanBP2 has SUMO1 E3 ligase activity

Pichler, A, Gast, A, Seeler, JS, Dejean, A, Melchior, F

Cell 2002
16194093 Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction

Cooper, HJ, Tatham, MH, Jaffray, E, Heath, JK, Lam, TT, Marshall, AG, Hay, RT

Anal. Chem. 2005
15378033 The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

Pichler, A, Knipscheer, P, Saitoh, H, Sixma, TK, Melchior, F

Nat. Struct. Mol. Biol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created