Reactome | SUMO2,3-K203,K486-PARP1 [nucleoplasm]

SUMO2,3-K203,K486-PARP1 [nucleoplasm]

Stable Identifier

R-HSA-4551617

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Poly (ADP-ribose) polymerase 1

Icon

Locations in the PathwayBrowser for interactor UniProt:P16104 H2AFX

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Literature References

PubMed ID	Title	Journal	Year
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
24782567	Proteome-wide identification of SUMO2 modification sites Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT	Sci Signal	2014
23750026	Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions Lamoliatte, F, Bonneil, E, Durette, C, Caron-Lizotte, O, Wildemann, D, Zerweck, J, Wenshuk, H, Thibault, P	Mol. Cell Proteomics	2013

External Reference Information

External Reference

UniProt:P09874 PARP1

Gene Names

PARP1, ADPRT, PPOL

Chain

initiator methionine:1, chain:2-1014

Reference Genes

BioGPS Gene:142 PARP1

COSMIC (genes):PARP1 PARP1

CTD Gene:142 PARP1

dbSNP Gene:142 PARP1

ENSEMBL:ENSG00000143799 PARP1

HGNC:270 PARP1

KEGG Gene (Homo sapiens):142 PARP1

Monarch:142 PARP1

NCBI Gene:142 PARP1

OMIM:173870 PARP1

UCSC:P09874 PARP1

Reference Transcript

RefSeq:NM_001618.3 PARP1

Other Identifiers

11726247_s_at

11726248_x_at

11726249_a_at

11745950_a_at

1287_at

142

147

16699739

1UK0

1UK1

1WOK

208644_at

2458786

2458787

2458788

2458789

2458790

2458791

2458792

2458796

2458797

2458801

2458803

2458805

2458806

2458808

2458810

2458813

2458816

2458817

2458818

2458819

2458820

2458821

2458823

2458825

2458827

2458828

2458829

2458832

2458838

2458839

2458840

2COK

2CR9

2CS2

2DMJ

2JVN

2L30

2L31

2N8A

2RCW

2RD6

2RIQ

3501577

3501611

3539486

3539490

3539492

3539496

3839

3840

3GJW

3GN7

3L3L

3L3M

3OD8

3ODA

3ODC

3ODE

41146_at

45168

4AV1

4DQY

4GV7

4HHY

4HHZ

4L6S

4OPX

4OQA

4OQB

4PJT

4R5W

4R6E

4RV6

4UND

4UXB

4XHU

4ZZZ

5A00

5DS3

5HA9

5KPN

5KPO

5KPP

5KPQ

5WRQ

5WRY

5WRZ

5WS0

5WS1

5WTC

5XSR

5XST

5XSU

6BHV

75726

75727

7924733

A0A024R3T8

A_33_P3236921

A_33_P3290338

AAA51599

AAA51663

AAA60000

AAA60137

AAA60155

AAB59447

AAH37545

AAM75364

AF524947

AL359704

AL359742

BC037545

CAA34663

CAA39606

CAB000147

CAB003839

CAB003840

CAB075726

CAB075727

CCDS1554

CH471098

EAW69783

EAW69784

ENSG00000143799

ENSP00000355759

ENST00000366794

ENST00000366794.9

EntrezGene:142

EntrezGene:PARP1

g190266_3p_at

GE81045

GO:0000122

GO:0000228

GO:0000715

GO:0000717

GO:0000723

GO:0000724

GO:0000784

GO:0000977

GO:0001228

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0003723

GO:0003950

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0006259

GO:0006281

GO:0006293

GO:0006294

GO:0006295

GO:0006296

GO:0006302

GO:0006366

GO:0006464

GO:0006471

GO:0006915

GO:0006950

GO:0006974

GO:0007005

GO:0007165

GO:0007179

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0009058

GO:0010332

GO:0010613

GO:0010990

GO:0016020

GO:0016540

GO:0016740

GO:0016757

GO:0018312

GO:0018424

GO:0019899

GO:0019901

GO:0022607

GO:0023019

GO:0030154

GO:0030225

GO:0030331

GO:0030592

GO:0032042

GO:0032869

GO:0032991

GO:0032993

GO:0033148

GO:0033683

GO:0034599

GO:0034641

GO:0034644

GO:0035861

GO:0036211

GO:0042592

GO:0042769

GO:0042802

GO:0042826

GO:0043167

GO:0043226

GO:0043504

GO:0044030

GO:0044281

GO:0045944

GO:0046332

GO:0046872

GO:0047485

GO:0048856

GO:0050790

GO:0051276

GO:0051287

GO:0051604

GO:0051901

GO:0060391

GO:0065003

GO:0070212

GO:0070213

GO:0070412

GO:0070911

GO:0071294

GO:0071560

GO:0090734

GO:0140294

GO:1900182

GO:1901216

GO:1903376

GO:1903518

GO:1903827

GO:1904044

GO:1904357

GO:1904646

GO:1904762

GO:1905168

GO:1990404

GO:1990966

GO:2000679

GO:2001170

HGNC:270

HPA045168

IPR001357

IPR001510

IPR004102

IPR008288

IPR008893

IPR012317

IPR012982

IPR036420

IPR036616

IPR036930

IPR036957

IPR038650

J03473

J03473_at

M17081

M18112

M29544

M29545

M29766

M29767

M29768

M29769

M29770

M29771

M29772

M29773

M29774

M29775

M29776

M29777

M29778

M29779

M29780

M29781

M29782

M29783

M29784

M29785

M29786

M32721

M60436

MIM:173870

NM_001618

NP_001609

PARP1

PARP1-203

PF00533

PF00644

PF00645

PF02877

PF05406

PF08063

PH_hs_0010559

Q5VX84

Q5VX85

SM00292

SM00773

SM01335

SM01336

TC01003876.hg

UPI000013D92D

X16674

X56140

X56141

Participant Of

output

PIAS4 SUMOylates PARP1 with SUMO2,3

Other forms of this molecule

SUMO1-K203,K486-PARP1 [nucleoplasm]

PAR-PARP1 [nucleoplasm]

PARP1 [nucleoplasm]

Inferred To

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Bos taurus)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Canis familiaris)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Danio rerio)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Drosophila melanogaster)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Gallus gallus)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Mus musculus)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Rattus norvegicus)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Sus scrofa)

SUMO2,3-K203,K486-PARP1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 203

Coordinate

203

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 486

Coordinate

486

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001609.2

ZINC - World Drugs

PARP1_HUMAN

OpenTargets

ENSG00000143799

ZINC - FDA approved

PARP1_HUMAN

ZINC - Substances

PARP1_HUMAN

ZINC target

P09874

ZINC - Biogenic

PARP1_HUMAN

PRO

P09874

PDB

4HHY, 5DS3, 4UXB, 5WRQ, 1UK1, 4XHU, 4DQY, 2CR9, 5A00, 5KPO, 2L30, 4OPX, 6GHK, 5WRZ, 4RV6, 4OQA, 2RIQ, 3ODA, 2COK, 4HHZ, 2L31, 5WRY, 5KPN, 2CS2, 5WTC, 3OD8, 5WS0, 3ODC, 4AV1, 3GN7, 4UND, 1UK0, 4R6E, 2RCW, 2DMJ, 4ZZZ, 5KPP, 4PJT, 4OQB, 5KPQ, 4R5W, 3ODE, 3L3M, 2N8A, 6BHV, 3L3L, 4L6S, 5HA9, 5WS1, 3GJW, 2RD6, 5XSU, 4GV7, 2JVN, 5XSR, 1WOK, 5XST

ZINC - Investigational

PARP1_HUMAN

ZINC - Metabolites

PARP1_HUMAN

GeneCards

P09874

ZINC - Predictions - Purchasable

PARP1_HUMAN

HMDB Protein

HMDBP00913

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13010 XRCC5	4	XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.839	9
UniProt:Q8IW19 APLF			0.837	8
UniProt:P16104 H2AFX	7	p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583)	0.798	10
UniProt:P12956 XRCC6	5	XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.757	7
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.75	5
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) SUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.739	8
UniProt:Q7Z2E3 APTX			0.706	9
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.669	6
UniProt:P46063 RECQ1			0.669	8
UniProt:P09874 PARP1	4	SUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) SUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.623	3
UniProt:P42574 CASP3	5	CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.623	2
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.609	3
UniProt:Q9Y530 OARD1			0.602	5
UniProt:Q8N2W9 PIAS4	2	SUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415) PIAS4 [nucleoplasm] (R-HSA-2993789)	0.602	5
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) TCF7L2 K485fs25* [nucleoplasm] (R-HSA-5334040) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.597	6
UniProt:BRCA2 ENSG00000139618			0.591	3
UniProt:Q86WJ1-1 CHD1L			0.591	3
UniProt:Q14684-1 RRP1B			0.584	4
UniProt:P11308 ERG			0.558	7
UniProt:P22415 USF1	1	USF1 [nucleoplasm] (R-HSA-9023562)	0.558	3
ChEBI:62878 XAV939			0.544	3
UniProt:Q02085 SNAI1			0.544	3
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) SUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.537	6
UniProt:Q14684 RRP1B			0.527	2
UniProt:P68431 HIST1H3A	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.527	3
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.527	5
UniProt:P54577 YARS	1	YARS [cytosol] (R-HSA-379560)	0.524	5
IntAct:EBI-11426955 1082A			0.524	3
UniProt:P0CG48 UBC	316	UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-566-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-338-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-186-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-262-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-414-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-110-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-642-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-488-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130) Ub-443-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783153) Ub-139-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783155) Ub-63-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783094) Ub-671-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783083) Ub-519-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783053) Ub-367-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783105) Ub-215-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783137) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122) Ub-310-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783027) Ub-234-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783157) Ub-614-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783063) Ub-462-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783118) Ub-538-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783011) Ub-158-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783140) Ub-82-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783175) Ub-315-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783089) Ub-163-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783091) Ub-543-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783060) Ub-239-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783092) Ub-619-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783125) Ub-467-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783181) Ub-11-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783104) Ub-391-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783170) Ub-87-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783110) Ub-656-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783134) Ub-124-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783120) Ub-428-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783090) Ub-48-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783029) Ub-504-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783113) Ub-200-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783150) Ub-580-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783119) Ub-276-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783183) Ub-352-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783201) Ub-29-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783064) Ub-182-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783097) Ub-486-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783194) Ub-334-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783199) Ub-638-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783188) Ub-106-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783031) Ub-258-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783016) Ub-562-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783172) Ub-410-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783077) Ub-636-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783128) Ub-104-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783032) Ub-256-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783004) Ub-484-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783156) Ub-27-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783022) Ub-332-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783138) Ub-180-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783107) Ub-408-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783108) Ub-560-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783174) N6-glycyl-L-lysine-UBC(457-532) [cytosol] (R-HSA-8869048) N6-glycyl-L-lysine-UBC(609-684) [cytosol] (R-HSA-8869052) N6-glycyl-L-lysine-UBC(229-304) [cytosol] (R-HSA-8869032) N6-glycyl-L-lysine-UBC(533-608) [cytosol] (R-HSA-8869033) N6-glycyl-L-lysine-UBC(153-228) [cytosol] (R-HSA-8869035) N6-glycyl-L-lysine-UBC(305-380) [cytosol] (R-HSA-8869036) N6-glycyl-L-lysine-UBC(77-152) [cytosol] (R-HSA-8869026) N6-glycyl-L-lysine-UBC(1-76) [cytosol] (R-HSA-8869030) N6-glycyl-L-lysine-UBC(381-456) [cytosol] (R-HSA-8869031) Ub-29-UBC(1-76) [cytosol] (R-HSA-5689165) Ub-258-UBC(229-304) [cytosol] (R-HSA-5689167) Ub-334-UBC(305-380) [cytosol] (R-HSA-5689166) Ub-410-UBC(381-456) [cytosol] (R-HSA-5689185) Ub-486-UBC(457-532) [cytosol] (R-HSA-5689176) Ub-562-UBC(533-608) [cytosol] (R-HSA-5689151) Ub-106-UBC(77-152) [cytosol] (R-HSA-5689183) Ub-182-UBC(153-228) [cytosol] (R-HSA-5689169) Ub-638-UBC(609-684) [cytosol] (R-HSA-5689136) Ub-310-UBC(305-380) [cytosol] (R-HSA-5689097) Ub-6-UBC(1-76) [cytosol] (R-HSA-5689091) Ub-462-UBC(457-532) [cytosol] (R-HSA-5689092) Ub-386-UBC(381-456) [cytosol] (R-HSA-5689086) Ub-538-UBC(533-608) [cytosol] (R-HSA-5689104) Ub-158-UBC(153-228) [cytosol] (R-HSA-5689107) Ub-614-UBC(609-684) [cytosol] (R-HSA-5689076) Ub-234-UBC(229-304) [cytosol] (R-HSA-5689110) Ub-82-UBC(77-152) [cytosol] (R-HSA-5689078) Ub-110-UBC(77-152) [cytosol] (R-HSA-5689196) Ub-33-UBC(1-76) [cytosol] (R-HSA-5689134) Ub-488-UBC(457-532) [cytosol] (R-HSA-5689153) Ub-338-UBC(305-380) [cytosol] (R-HSA-5689152) Ub-642-UBC(609-684) [cytosol] (R-HSA-5689218) Ub-414-UBC(381-456) [cytosol] (R-HSA-5689157) Ub-262-UBC(229-304) [cytosol] (R-HSA-5689150) Ub-566-UBC(533-608) [cytosol] (R-HSA-5689205) Ub-186-UBC(153-228) [cytosol] (R-HSA-5689140) adenylatedG608-UBC(533-608) [nucleoplasm] (R-HSA-8852090) adenylatedG380-UBC(305-380) [nucleoplasm] (R-HSA-8852093) adenylatedG532-UBC(457-532) [nucleoplasm] (R-HSA-8852081) adenylatedG304-UBC(229-304) [nucleoplasm] (R-HSA-8852050) adenylatedG152-UBC(77-152) [nucleoplasm] (R-HSA-8852054) adenylatedG684-UBC(609-684) [nucleoplasm] (R-HSA-8852105) adenylatedG228-UBC(153-228) [nucleoplasm] (R-HSA-8852075) adenylatedG76-UBC(1-76) [nucleoplasm] (R-HSA-8852044) adenylatedG456-UBC(381-456) [nucleoplasm] (R-HSA-8852098) UBC [cytosol] (R-HSA-8853531) adenylatedG380-UBC(305-380) [cytosol] (R-HSA-8852062) adenylatedG608-UBC(533-608) [cytosol] (R-HSA-8852052) adenylatedG76-UBC(1-76) [cytosol] (R-HSA-8852053) adenylatedG304-UBC(229-304) [cytosol] (R-HSA-8852117) adenylatedG684-UBC(609-684) [cytosol] (R-HSA-8852118) adenylatedG152-UBC(77-152) [cytosol] (R-HSA-8852087) adenylatedG532-UBC(457-532) [cytosol] (R-HSA-8852045) adenylatedG228-UBC(153-228) [cytosol] (R-HSA-8852111) adenylatedG456-UBC(381-456) [cytosol] (R-HSA-8852069) Ub-428-UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943062) Ub-656-UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943120) Ub-124-UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943129) Ub-48-UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943079) Ub-352-UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943108) Ub-504-UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943075) Ub-276-UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943106) Ub-580-UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943137) Ub-200-UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943087) UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943095) UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943126) UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943061) UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943135) UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943103) UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943068) UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943077) UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943084) UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943112) UBC(1-76) [plasma membrane] (R-HSA-3149469) UBC(457-532) [plasma membrane] (R-HSA-3149468) UBC(153-228) [plasma membrane] (R-HSA-3149467) UBC(609-684) [plasma membrane] (R-HSA-3149466) UBC(77-152) [plasma membrane] (R-HSA-3149465) UBC(229-304) [plasma membrane] (R-HSA-3149464) UBC(533-608) [plasma membrane] (R-HSA-3149462) UBC(381-456) [plasma membrane] (R-HSA-3149459) UBC(305-380) [plasma membrane] (R-HSA-3149458) UBC(1-76) [endosome membrane] (R-HSA-939187) UBC(533-608) [endosome membrane] (R-HSA-939221) UBC(77-152) [endosome membrane] (R-HSA-939161) UBC(305-380) [endosome membrane] (R-HSA-939196) UBC(457-532) [endosome membrane] (R-HSA-939199) UBC(381-456) [endosome membrane] (R-HSA-939166) UBC(153-228) [endosome membrane] (R-HSA-939170) UBC(609-684) [endosome membrane] (R-HSA-939237) UBC(229-304) [endosome membrane] (R-HSA-939172) Ub-256-UBC(229-304) [cytosol] (R-HSA-5689135) Ub-180-UBC(153-228) [cytosol] (R-HSA-5689221) Ub-104-UBC(77-152) [cytosol] (R-HSA-5689189) Ub-484-UBC(457-532) [cytosol] (R-HSA-5689220) Ub-560-UBC(533-608) [cytosol] (R-HSA-5689145) Ub-636-UBC(609-684) [cytosol] (R-HSA-5689144) Ub-332-UBC(305-380) [cytosol] (R-HSA-5689211) Ub-27-UBC(1-76) [cytosol] (R-HSA-5689179) Ub-408-UBC(381-456) [cytosol] (R-HSA-5689182) Ub-87-UBC(77-152) [cytosol] (R-HSA-3095920) Ub-163-UBC(153-228) [cytosol] (R-HSA-3095924) Ub-619-UBC(609-684) [cytosol] (R-HSA-3095925) Ub-467-UBC(457-532) [cytosol] (R-HSA-3095935) Ub-11-UBC(1-76) [cytosol] (R-HSA-3095906) Ub-543-UBC(533-608) [cytosol] (R-HSA-3095912) Ub-391-UBC(381-456) [cytosol] (R-HSA-3095914) Ub-315-UBC(305-380) [cytosol] (R-HSA-3095916) Ub-239-UBC(229-304) [cytosol] (R-HSA-3095919) Ub-519-UBC(457-532) [endosome membrane] (R-HSA-939227) Ub-367-UBC(305-380) [endosome membrane] (R-HSA-939162) Ub-291-UBC(229-304) [endosome membrane] (R-HSA-939226) Ub-443-UBC(381-456) [endosome membrane] (R-HSA-939204) Ub-215-UBC(153-228) [endosome membrane] (R-HSA-939175) Ub-63-UBC(1-76) [endosome membrane] (R-HSA-939174) Ub-595-UBC(533-608) [endosome membrane] (R-HSA-939242) Ub-139-UBC(77-152) [endosome membrane] (R-HSA-939244) Ub-671-UBC(609-684) [endosome membrane] (R-HSA-939183) Ub-291-UBC(229-304) [plasma membrane] (R-HSA-939859) Ub-595-UBC(533-608) [plasma membrane] (R-HSA-939858) Ub-367-UBC(305-380) [plasma membrane] (R-HSA-939861) Ub-63-UBC(1-76) [plasma membrane] (R-HSA-939860) Ub-139-UBC(77-152) [plasma membrane] (R-HSA-939865) Ub-215-UBC(153-228) [plasma membrane] (R-HSA-939864) Ub-519-UBC(457-532) [plasma membrane] (R-HSA-939845) Ub-671-UBC(609-684) [plasma membrane] (R-HSA-939846) Ub-443-UBC(381-456) [plasma membrane] (R-HSA-939848) Ub-408-UBC(381-456) [nucleoplasm] (R-HSA-6782681) Ub-484-UBC(457-532) [nucleoplasm] (R-HSA-6782650) Ub-104-UBC(77-152) [nucleoplasm] (R-HSA-6782651) Ub-256-UBC(229-304) [nucleoplasm] (R-HSA-6782641) Ub-180-UBC(153-228) [nucleoplasm] (R-HSA-6782603) Ub-560-UBC(533-608) [nucleoplasm] (R-HSA-6782637) Ub-27-UBC(1-76) [nucleoplasm] (R-HSA-6782625) Ub-636-UBC(609-684) [nucleoplasm] (R-HSA-6782597) Ub-332-UBC(305-380) [nucleoplasm] (R-HSA-6782630) Ub-638-UBC(609-684) [nucleoplasm] (R-HSA-6782680) Ub-258-UBC(229-304) [nucleoplasm] (R-HSA-6782621) Ub-562-UBC(533-608) [nucleoplasm] (R-HSA-6782672) Ub-410-UBC(381-456) [nucleoplasm] (R-HSA-6782642) Ub-182-UBC(153-228) [nucleoplasm] (R-HSA-6782678) Ub-106-UBC(77-152) [nucleoplasm] (R-HSA-6782602) Ub-334-UBC(305-380) [nucleoplasm] (R-HSA-6782638) Ub-29-UBC(1-76) [nucleoplasm] (R-HSA-6782659) Ub-486-UBC(457-532) [nucleoplasm] (R-HSA-6782661) Ub-671-UBC(609-684) [nucleoplasm] (R-HSA-6782523) Ub-215-UBC(153-228) [nucleoplasm] (R-HSA-6782491) Ub-63-UBC(1-76) [nucleoplasm] (R-HSA-6782492) Ub-443-UBC(381-456) [nucleoplasm] (R-HSA-6782480) Ub-367-UBC(305-380) [nucleoplasm] (R-HSA-6782479) Ub-139-UBC(77-152) [nucleoplasm] (R-HSA-6782496) Ub-519-UBC(457-532) [nucleoplasm] (R-HSA-6782497) Ub-595-UBC(533-608) [nucleoplasm] (R-HSA-6782499) Ub-291-UBC(229-304) [nucleoplasm] (R-HSA-6782500) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-6782524) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-6782462) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-6782512) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-6782482) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-6782487) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-6782474) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-6782477) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-6782498) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-6782467) Ub-467-UBC(457-532) [nucleoplasm] (R-HSA-6782619) Ub-163-UBC(153-228) [nucleoplasm] (R-HSA-6782622) Ub-11-UBC(1-76) [nucleoplasm] (R-HSA-6782609) Ub-87-UBC(77-152) [nucleoplasm] (R-HSA-6782632) Ub-239-UBC(229-304) [nucleoplasm] (R-HSA-6782669) Ub-543-UBC(533-608) [nucleoplasm] (R-HSA-6782594) Ub-391-UBC(381-456) [nucleoplasm] (R-HSA-6782626) Ub-315-UBC(305-380) [nucleoplasm] (R-HSA-6782660) Ub-619-UBC(609-684) [nucleoplasm] (R-HSA-6782662) Ub-186-UBC(153-228) [nucleoplasm] (R-HSA-6782617) Ub-338-UBC(305-380) [nucleoplasm] (R-HSA-6782620) Ub-33-UBC(1-76) [nucleoplasm] (R-HSA-6782653) Ub-110-UBC(77-152) [nucleoplasm] (R-HSA-6782590) Ub-262-UBC(229-304) [nucleoplasm] (R-HSA-6782640) Ub-642-UBC(609-684) [nucleoplasm] (R-HSA-6782674) Ub-566-UBC(533-608) [nucleoplasm] (R-HSA-6782646) Ub-414-UBC(381-456) [nucleoplasm] (R-HSA-6782636) Ub-488-UBC(457-532) [nucleoplasm] (R-HSA-6782599) Ub-82-UBC(77-152) [nucleoplasm] (R-HSA-6782675) Ub-6-UBC(1-76) [nucleoplasm] (R-HSA-6782611) Ub-234-UBC(229-304) [nucleoplasm] (R-HSA-6782677) Ub-158-UBC(153-228) [nucleoplasm] (R-HSA-6782645) Ub-310-UBC(305-380) [nucleoplasm] (R-HSA-6782614) Ub-538-UBC(533-608) [nucleoplasm] (R-HSA-6782664) Ub-462-UBC(457-532) [nucleoplasm] (R-HSA-6782634) Ub-386-UBC(381-456) [nucleoplasm] (R-HSA-6782605) Ub-614-UBC(609-684) [nucleoplasm] (R-HSA-6782657) UBC(229-304) [nucleoplasm] (R-HSA-939857) UBC(381-456) [nucleoplasm] (R-HSA-939856) UBC(305-380) [nucleoplasm] (R-HSA-939863) UBC(457-532) [nucleoplasm] (R-HSA-939862) UBC(533-608) [nucleoplasm] (R-HSA-939866) UBC(77-152) [nucleoplasm] (R-HSA-939869) UBC(609-684) [nucleoplasm] (R-HSA-939868) UBC(1-76) [nucleoplasm] (R-HSA-939871) UBC(153-228) [nucleoplasm] (R-HSA-939853) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-5683048) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-5683050) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-5683041) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-5683042) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-5683045) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-5683046) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-5683033) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-5683035) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-5683039) Ub-671-UBC(609-684) [nucleoplasm] (R-HSA-5682857) Ub-139-UBC(77-152) [nucleoplasm] (R-HSA-5682856) Ub-519-UBC(457-532) [nucleoplasm] (R-HSA-5682848) Ub-63-UBC(1-76) [nucleoplasm] (R-HSA-5682852) Ub-595-UBC(533-608) [nucleoplasm] (R-HSA-5682841) Ub-215-UBC(153-228) [nucleoplasm] (R-HSA-5682840) Ub-443-UBC(381-456) [nucleoplasm] (R-HSA-5682843) Ub-291-UBC(229-304) [nucleoplasm] (R-HSA-5682842) Ub-367-UBC(305-380) [nucleoplasm] (R-HSA-5682837) Ub-48-UBC(1-76) [cytosol] (R-HSA-939219) Ub-656-UBC(609-684) [cytosol] (R-HSA-939255) Ub-428-UBC(381-456) [cytosol] (R-HSA-939190) Ub-504-UBC(457-532) [cytosol] (R-HSA-939257) Ub-580-UBC(533-608) [cytosol] (R-HSA-939256) Ub-276-UBC(229-304) [cytosol] (R-HSA-939207) Ub-124-UBC(77-152) [cytosol] (R-HSA-939209) Ub-200-UBC(153-228) [cytosol] (R-HSA-939179) Ub-352-UBC(305-380) [cytosol] (R-HSA-939181) UBC(457-532) [cytosol] (R-HSA-939184) UBC(1-76) [cytosol] (R-HSA-939188) UBC(381-456) [cytosol] (R-HSA-939191) UBC(229-304) [cytosol] (R-HSA-939192) UBC(153-228) [cytosol] (R-HSA-939258) UBC(609-684) [cytosol] (R-HSA-939165) UBC(77-152) [cytosol] (R-HSA-939164) UBC(305-380) [cytosol] (R-HSA-939232) UBC(533-608) [cytosol] (R-HSA-939239) Ub-215-UBC(153-228) [cytosol] (R-HSA-939186) Ub-139-UBC(77-152) [cytosol] (R-HSA-939254) Ub-595-UBC(533-608) [cytosol] (R-HSA-939198) Ub-291-UBC(229-304) [cytosol] (R-HSA-939173) Ub-367-UBC(305-380) [cytosol] (R-HSA-939206) Ub-671-UBC(609-684) [cytosol] (R-HSA-939241) Ub-63-UBC(1-76) [cytosol] (R-HSA-939176) Ub-519-UBC(457-532) [cytosol] (R-HSA-939212) Ub-443-UBC(381-456) [cytosol] (R-HSA-939182)	0.524	2
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	2
UniProt:P49715 CEBPA	1	CEBPA [nucleoplasm] (R-HSA-381289)	0.499	2
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.463	10
UniProt:Q5T7N2 LITD1			0.462	5
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.462	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:P11387 TOP1	2	SUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.462	3
UniProt:P11388 TOP2A	3	SUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) TOP2A [nucleoplasm] (R-HSA-1362276) SUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.462	2