PIAS4 SUMOylates PARP1 with SUMO1

Stable Identifier
R-HSA-4551604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO1 (Martin et al. 2009, Matafora et al. 2009, Messner et al. 2009, Zilio et al. 2013, Impens et al. 2014). SUMOylation abrogates acetylation of PARP1 by p300 (Messner et al. 2009). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). PARP1 is SUMOylated in response to heat shock and SUMOylation is required for full activation of the HSP70.1 promoter (Martin et al 2009).

Literature References
PubMed ID Title Journal Year
23871147 DNA-dependent SUMO modification of PARP-1

Zilio, N, Williamson, CT, Eustermann, S, Shah, R, West, SC, Neuhaus, D, Ulrich, HD

DNA Repair (Amst.) 2013
19779455 PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

Martin, N, Schwamborn, K, Schreiber, V, Werner, A, Guillier, C, Zhang, XD, Bischof, O, Seeler, JS, Dejean, A

EMBO J. 2009
19596686 Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition

Matafora, V, D'Amato, A, Mori, S, Blasi, F, Bachi, A

Mol. Cell Proteomics 2009
19622798 Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

Messner, S, Schuermann, D, Altmeyer, M, Kassner, I, Schmidt, D, Schär, P, Müller, S, Hottiger, MO

FASEB J. 2009
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created