Reactome | SUMO2-VDR [nucleoplasm]

SUMO2-VDR [nucleoplasm]

Stable Identifier

R-HSA-4546376

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Vitamin D3 receptor, VDR_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
22564762	PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor Jena, S, Lee, WP, Doherty, D, Thompson, PD	J. Steroid Biochem. Mol. Biol.	2012

External Reference Information

External Reference

UniProt:P11473 VDR

Gene Names

VDR, NR1I1

Chain

chain:1-427

Reference Genes

BioGPS Gene:7421 VDR

COSMIC (genes):VDR VDR

CTD Gene:7421 VDR

dbSNP Gene:7421 VDR

ENSEMBL:ENSG00000111424 VDR

HGNC:12679 VDR

KEGG Gene (Homo sapiens):7421 VDR

Monarch:7421 VDR

NCBI Gene:7421 VDR

OMIM:601769 VDR

UCSC:P11473 VDR

Reference Transcript

Other Identifiers

0006620095

0106020070

11728776_s_at

11728777_a_at

11750983_a_at

11758546_x_at

1388_g_at

1410_at

16763764

1DB1

1IE8

1IE9

1KB2

1KB4

1KB6

1S0Z

1S19

1TXI

1YNW

204253_s_at

204254_s_at

204255_s_at

2HAM

2HAR

2HAS

2HB7

2HB8

3452817

3452819

3452820

3452821

3452822

3452824

3452825

3452827

3452831

3452833

3452835

3452842

3452848

3452849

3A2I

3A2J

3A3Z

3A40

3A78

3AUQ

3AUR

3AX8

3AZ1

3AZ2

3AZ3

3B0T

3CS4

3CS6

3KPZ

3M7R

3OGT

3P8X

3TKC

3VHW

3W0A

3W0C

3W0Y

3WGP

3WWR

3X31

3X36

4617

47740

4G2I

4ITE

4ITF

57460_at

5GT4

5V39

5YSY

5YT2

7421

7962689

A_23_P162589

AAA61273

AAA61274

AAB95155

AAH60832

AAP88938

AAV85448

AB002168

AC004466

AC121338

ADZ17347

AF026260

AK312267

AY342401

AY827087

BAA83389

BAG35198

BC060832

CAA47824

CAB004617

CCDS55820

CCDS8757

CH471111

EAW57960

EAW57961

EAW57962

EAW57963

ENSG00000111424

ENSP00000229022

ENSP00000378734

ENSP00000447173

ENSP00000449573

ENST00000229022

ENST00000229022.7

ENST00000395324

ENST00000395324.6

ENST00000549336

ENST00000549336.5

ENST00000550325

ENST00000550325.5

EntrezGene:7421

EntrezGene:VDR

F1D8P8

F8VPF8

F8VRJ4

F8VVY8

F8VXQ9

g4507882_3p_a_at

GE57479

GO:0000003

GO:0000122

GO:0000902

GO:0000976

GO:0000977

GO:0000981

GO:0001501

GO:0003674

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005499

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0006367

GO:0006629

GO:0006810

GO:0006816

GO:0006874

GO:0007165

GO:0007275

GO:0007595

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0008285

GO:0008289

GO:0009058

GO:0009887

GO:0010628

GO:0010839

GO:0010980

GO:0030154

GO:0030374

GO:0030522

GO:0032991

GO:0034641

GO:0038023

GO:0038183

GO:0038186

GO:0042359

GO:0042592

GO:0043167

GO:0043226

GO:0043235

GO:0043401

GO:0043565

GO:0044281

GO:0045618

GO:0045892

GO:0045944

GO:0046697

GO:0046872

GO:0046965

GO:0048856

GO:0050892

GO:0060058

GO:0060558

GO:0060745

GO:0070561

GO:0070644

GO:0090575

GO:1902098

GO:1902121

HGNC:12679

HPA047740

HQ692836

Hs.2062.0.A2_3p_a_at

Hs.2062.0.A3_3p_a_at

ILMN_1666203

ILMN_1794337

ILMN_1869034

ILMN_2319952

IPR000324

IPR000536

IPR001628

IPR001723

IPR013088

IPR035500

J03258

J03258_at

M65208

MIM:166710

MIM:277440

MIM:601769

NM_000376

NM_001017535

NM_001017536

NM_001364085

NP_000367

NP_001017535

NP_001017536

NP_001351014

NR1i1

PF00104

PF00105

PH_hs_0000277

PR00047

PR00350

PR00398

SM00399

SM00430

TC12001439.hg

TC12002858.hg

UPI000003C12F

UPI000015B2DC

VDR

VDR-201

VDR-202

VDR-206

VDR-208

X67482

XM_006719587

XM_011538720

XM_024449178

XP_006719650

XP_011537022

XP_024304946

Participant Of

output

PIAS4 SUMOylates VDR with SUMO2

Other forms of this molecule

VDR [nucleoplasm]

Inferred To

Homologues of SUMO2-VDR [nucleoplasm] (Drosophila melanogaster)

SUMO2-VDR [nucleoplasm] (Canis familiaris)

SUMO2-VDR [nucleoplasm] (Drosophila melanogaster)

SUMO2-VDR [nucleoplasm] (Mus musculus)

SUMO2-VDR [nucleoplasm] (Rattus norvegicus)

SUMO2-VDR [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at unknown position

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001017535.1, XP_011537022.1, NP_000367.1, XP_006719650.1, NP_001017536.1

ZINC - World Drugs

VDR_HUMAN

OpenTargets

ENSG00000111424

ZINC - FDA approved

VDR_HUMAN

ZINC - Substances

VDR_HUMAN

ZINC - Biogenic

VDR_HUMAN

ZINC target

P11473

PRO

P11473

PDB

2HB7, 1IE9, 4G2I, 2HAS, 2HAR, 3A78, 1S19, 1S0Z, 5GT4, 1IE8, 2HAM, 1YNW, 3KPZ, 3X36, 1KB2, 4ITF, 3TKC, 2HB8, 5V39, 1DB1, 4ITE, 3AZ3, 3A40, 3A3Z, 3AX8, 3WWR, 3AZ1, 3AUQ, 3AUR, 1KB6, 1KB4, 3W0C, 3W0A, 3B0T, 3M7R, 3OGT, 3X31, 3A2J, 5YT2, 3VHW, 5YSY, 3AZ2, 3CS6, 3P8X, 3WGP, 3A2I, 3W0Y, 1TXI, 3CS4

ZINC - Investigational

VDR_HUMAN

ZINC - Metabolites

VDR_HUMAN

GeneCards

P11473

ZINC - Predictions - Purchasable

VDR_HUMAN

Orphanet

15707

HMDB Protein

HMDBP01798

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19793 RXRA	4	p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.791	6
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.743	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.667	5
UniProt:Q15788 NCOA1	3	NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) SUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 [nucleoplasm] (R-HSA-442496)	0.656	3
UniProt:Q13501 SQSTM1	2	SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.591	4
UniProt:P28700 Rxra	5	phospho-p-S21-RXRA [nucleoplasm] (R-MMU-5334811) RXRA [cytosol] (R-MMU-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-MMU-4341130) Rxra [nucleoplasm] (R-MMU-442483) RXRA [nucleoplasm] (R-MMU-381319)	0.576	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q15645 PCH2			0.556	3
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.547	3
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.537	6
IntAct:EBI-9915211 CO1A1			0.524	2
UniProt:P26045 PTPN3	1	PTPN3 [plasma membrane] (R-HSA-5490317)	0.524	4
UniProt:Q15596 NCOA2	3	NCOA2 (869-1464) [nucleoplasm] (R-HSA-5603186) SUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (R-HSA-4085305) NCOA2 [nucleoplasm] (R-HSA-376398)	0.524	2
UniProt:Q9JLI4	1	NCOA6 [nucleoplasm] (R-RNO-376414)	0.508	2