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JAK1 [cytosol]
Stable Identifier
R-HSA-451898
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase JAK1, JAK1_HUMAN, Janus kinase 1
Icon
Locations in the PathwayBrowser for interactor UniProt:O75886%20STAM2
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
IL27RA binds JAK1 (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
IL2RB binds JAK1 (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
Interleukin-9 signaling (Homo sapiens)
IL9R binds JAK1 (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IL22RA1 binds JAK1 (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
JAK1 binds IFNLR1 (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
JAK1 binds IL20RA (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
JAK1 binds IL7R (Homo sapiens)
JAK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23458 JAK1
Gene Names
JAK1, JAK1A, JAK1B
Chain
chain:1-1154
Reference Genes
BioGPS Gene:3716 JAK1
COSMIC (genes):JAK1 JAK1
CTD Gene:3716 JAK1
dbSNP Gene:3716 JAK1
ENSEMBL:ENSG00000162434 JAK1
ENSEMBL_homo_sapiens_GENE:ENSG00000162434.14 JAK1
HGNC:6190 JAK1
KEGG Gene (Homo sapiens):3716 JAK1
Monarch:3716 JAK1
NCBI Gene:3716 JAK1
OMIM:147795 JAK1
UCSC:P23458 JAK1
Reference Transcript
RefSeq:NM_001321856.1 JAK1
RefSeq:NM_001321852.1 JAK1
RefSeq:NM_001321855.1 JAK1
RefSeq:NM_001320923.1 JAK1
RefSeq:NM_001321854.1 JAK1
RefSeq:NM_002227.3 JAK1
RefSeq:NM_001321853.1 JAK1
Other Identifiers
11717685_at
11717686_a_at
11717687_a_at
1457_at
1552610_PM_a_at
1552610_a_at
1552611_PM_a_at
1552611_a_at
16688164
16688214
201648_PM_at
201648_at
2416521
2416523
2416524
2416525
2416526
2416528
2416529
2416530
2416531
2416532
2416534
2416535
2416536
2416537
2416541
2416542
2416544
2416545
2416549
2416553
2416556
2416558
2416559
2416561
2416566
2416568
2416569
2416570
2416593
2416594
2416595
2416709
2416711
34877_at
3716
41594_at
7916747
A_21_P0001139
A_24_P410678
A_33_P3784283
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006468
GO:0007155
GO:0007259
GO:0009898
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019903
GO:0023052
GO:0030154
GO:0030155
GO:0031234
GO:0031410
GO:0031625
GO:0031730
GO:0034112
GO:0035556
GO:0035723
GO:0035771
GO:0036211
GO:0038110
GO:0038113
GO:0038154
GO:0038196
GO:0043226
GO:0046677
GO:0046872
GO:0048856
GO:0051239
GO:0060333
GO:0060337
GO:0060397
GO:0070102
GO:0072540
GO:0098542
GO:0098586
GO:0140096
GO:0150105
GO:1900182
GO:1903672
HMNXSV003011048
HMNXSV003020647
Hs.50651.0.S2_3p_at
Hs2.50651.1.S1_3p_s_at
Hs2.50651.1.S2_3p_s_at
ILMN_1793384
M64174_at
PH_hs_0025462
TC01002741.hg
TC01002747.hg
TC01005542.hg
p232
Participates
as a component of
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL13:IL13RA:TYK2:IL4R:JAK2:JAK1 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
CSF3R:LYN:JAK1 [plasma membrane] (Homo sapiens)
IL22RA1:JAK1 [plasma membrane] (Homo sapiens)
IL10RA:JAK1 [plasma membrane] (Homo sapiens)
IL20RA:JAK1 [plasma membrane] (Homo sapiens)
IL21R:JAK1 [plasma membrane] (Homo sapiens)
IL7R:JAK1 [plasma membrane] (Homo sapiens)
p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL9R:JAK1 [plasma membrane] (Homo sapiens)
p-Y407-IL9R:JAK1 [plasma membrane] (Homo sapiens)
OSMR:JAK1 [plasma membrane] (Homo sapiens)
IL31RA:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
as an input of
IL27RA binds JAK1 (Homo sapiens)
JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)
IL22RA1 binds JAK1 (Homo sapiens)
JAK1 binds IL20RA (Homo sapiens)
JAK1 binds IL7R (Homo sapiens)
IL9R binds JAK1 (Homo sapiens)
JAK1 binds IFNLR1 (Homo sapiens)
JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)
IL2RB binds JAK1 (Homo sapiens)
as a member of
ISG15 targets [cytosol] (Homo sapiens)
JAK1, JAK2, (TYK2) [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y1034,Y1035-JAK1 [cytosol]
JAK1 [endosome]
p-JAK1 [cytosol]
p-Y1034-JAK1 [cytosol]
p-Y-JAK1 [cytosol]
Inferred To
JAK1 [cytosol]
(Bos taurus)
JAK1 [cytosol]
(Canis familiaris)
JAK1 [cytosol]
(Danio rerio)
JAK1 [cytosol]
(Drosophila melanogaster)
JAK1 [cytosol]
(Gallus gallus)
JAK1 [cytosol]
(Mus musculus)
JAK1 [cytosol]
(Rattus norvegicus)
JAK1 [cytosol]
(Sus scrofa)
JAK1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001308785.1
,
NP_001308783.1
,
NP_001308782.1
,
NP_001307852.1
,
NP_002218.2
,
NP_001308784.1
,
NP_001308781.1
ZINC - World Drugs
JAK1_HUMAN
Guide to Pharmacology - Targets
2047
OpenTargets
ENSG00000162434
ZINC - FDA approved
JAK1_HUMAN
ZINC - Substances
JAK1_HUMAN
ZINC - Biogenic
JAK1_HUMAN
ZINC target
P23458
PRO
P23458
PDB
4K6Z
,
6SMB
,
4E4N
,
5HX8
,
4IVD
,
6BBU
,
4E4L
,
4L01
,
6N77
,
4L00
,
6RSD
,
4IVC
,
6N7D
,
5WO4
,
6HZU
,
4FK6
,
6W8L
,
6N79
,
4GS0
,
6SM8
,
6N7A
,
4EI4
,
4EHZ
,
5E1E
,
6GGH
,
4K77
,
5KHW
,
3EYH
,
6C7Y
,
3EYG
,
6RSB
,
6N7C
,
6RSC
,
6DBN
,
6ELR
,
4E5W
,
6N78
,
4IVB
,
4I5C
,
5IXI
,
6RSE
,
6AAH
,
6TPE
,
5IXD
,
8EXJ
,
5KHX
,
6TPF
,
6RSH
,
5L04
,
6N7B
ZINC - Investigational
JAK1_HUMAN
GeneCards
P23458
HPA
ENSG00000162434-JAK1
Ensembl
ENSP00000499884
,
ENST00000671929
,
ENST00000671954
,
ENST00000672247
,
ENST00000672751
,
ENSP00000499900
,
ENSP00000514243
,
ENST00000699262
,
ENSP00000343204
,
ENSP00000500841
,
ENSP00000514291
,
ENST00000342505
,
ENSP00000500745
,
ENST00000672179
,
ENST00000672434
,
ENSP00000500296
,
ENST00000699312
,
ENSG00000162434
,
ENSP00000500485
Pharos - Targets
P23458
ZINC - Predictions - Purchasable
JAK1_HUMAN
HMDB Protein
HMDBP01309
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.757
6
UniProt:P48551 IFNAR2
0.591
3
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.564
2
UniProt:P40189-1 IL6ST
1
p-5Y-IL6ST-1 [plasma membrane]
(R-HSA-1112580)
0.556
3
UniProt:O75886 STAM2
2
Ub-STAM2 [cytosol]
(R-HSA-6782781)
STAM2 [cytosol]
(R-HSA-182965)
0.502
2
UniProt:O60674 JAK2
8
p-Y1007,Y1008-JAK2 [cytosol]
(R-HSA-9005327)
p-JAK2 [cytosol]
(R-HSA-210621)
p-Y813-JAK2 [cytosol]
(R-HSA-997248)
JAK2 V617F [nucleoplasm]
(R-HSA-5211269)
JAK2 [endosome lumen]
(R-HSA-2002372)
p-12Y-JAK2 [cytosol]
(R-HSA-2586516)
p-Y1007-JAK2 [cytosol]
(R-HSA-873799)
JAK2 [cytosol]
(R-HSA-210620)
0.463
4
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