p-S193-KSRP binds 14-3-3zeta in the nucleus

Stable Identifier
R-HSA-450620
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which impairs the ability of KSRP to destabilize RNA. Thus the RNAs become stabilized. KSRP is able to shuttle between the nucleus and the cytoplasm. 14-3-3zeta is nucleoplasmic. Binding of KSRP to 14-3-3zeta causes KSRP to be retained in the nucleus.

Literature References
PubMed ID Title Journal Year
19198587 Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

Diaz-Moreno, I, Hollingworth, D, Frenkiel, TA, Kelly, G, Martin, S, Howell, S, Garcia-Mayoral, M, Gherzi, R, Briata, P, Ramos, A

Nat Struct Mol Biol 2009
Participants
Participant Of
Orthologous Events
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Created