Reactome | KSRP binds AU-rich element in 3' UTR of mRNA

KSRP binds AU-rich element in 3' UTR of mRNA

Stable Identifier

R-HSA-450592

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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KSRP binds AU-rich element in 3' UTR of mRNA

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KSRP (KHSRP) binds AU-rich regions of target RNAs via its four K-homology (KH) domains (Syswam et al. 2005, Ruggiero et al. 2007, Garcia-Mayoral et al. 2008, Li et al. 2009, Schmidt et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19141871	Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements Zhou, Y, Chen, W, Liu, J, Abidi, P, Sharpe, O, Li, H, Kraemer, FB, Robinson, WH	J Lipid Res	2009
17437629	Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling Khabar, KS, Ruggiero, T, Chen, CY, Trabucchi, M, Gherzi, R, Ponassi, M, Briata, P, al-Haj, L, Corte, G	BMC Mol Biol	2007
15514971	IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR Yang, X, Suswam, EA, Huang, Y, Nabors, LB, King, PH	Int J Cancer	2005
19854161	Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes Kleinert, H, Rauschkolb, P, Art, J, Pautz, A, Jung, M, Goldring, MB, Erkel, G, Schmidt, N	Biochem Pharmacol	2010
18684992	The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets Ramos, A, Garcia-Mayoral, MF, Diaz-Moreno, I, Hollingworth, D	Nucleic Acids Res	2008