Reactome | ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs

ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs

Stable Identifier

R-HSA-450400

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs

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Tristetraprolin (TTP) binds UUAUUUAUU motifs in the AU-rich elements of mRNAs. TTP binds Transportin-1 (Importin beta-2) which plays a role in shuttling TTP between P-bodies and stress granules.

Literature References

PubMed ID	Title	Journal	Year
18367721	Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation Deleault, KM, Gross, RH, Townley-Tilson, WH, Brooks, SA, Emmons, J, Whitfield, ML, Skinner, SJ	RNA	2008
19729507	A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay Tarn, WY, Chang, WL	Nucleic Acids Res	2009
12646273	Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases Dzineku, F, Blackshear, PJ, Cao, H	Arch Biochem Biophys	2003
17133347	Tristetraprolin recruits functional mRNA decay complexes to ARE sequences Williams, DA, Walsh, RJ, Hau, HH, Ogilvie, RL, Bohjanen, PR, Reilly, CS	J Cell Biochem	2007
12324455	RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein Applegate, JL, Arseneau, KO, Pizarro, TT, Pelo, JW, Sachedina, MA, Worthington, MT	J Biol Chem	2002
15117938	RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs Malicka, J, Wilson, GM, Brewer, BY, Blackshear, PJ	J Biol Chem	2004
12705825	Selective RNA binding by a single CCCH zinc-binding domain from Nup475 (Tristetraprolin) Michel, SL, Berg, JM, Guerrerio, AL	Biochemistry	2003
12639954	Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates Brewer, G, Guan, X, Zhou, P, Kennington, EA, Lai, WS, Wilson, GM, Blackshear, PJ	J Biol Chem	2003
10330172	Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA Kennington, EA, Carballo, E, Lai, WS, Strum, JR, Phillips, RS, Blackshear, PJ	Mol Cell Biol	1999
17369404	TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements Franks, TM, Lykke-Andersen, J	Genes Dev	2007