Reactome | CASP1(317-404) [cytosol]

CASP1(317-404) [cytosol]

Stable Identifier

R-HSA-448704

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CASP1 p10, Caspase-1 subunit p10, CASP1, CASP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P29466 CASP1

Gene Names

CASP1, IL1BC, IL1BCE

Chain

propeptide:1-119, chain:120-297, propeptide:298-316, chain:317-404

Reference Genes

BioGPS Gene:834 CASP1

COSMIC (genes):CASP1 CASP1

CTD Gene:834 CASP1

dbSNP Gene:834 CASP1

ENSEMBL:ENSG00000137752 CASP1

HGNC:1499 CASP1

KEGG Gene (Homo sapiens):834 CASP1

Monarch:834 CASP1

NCBI Gene:834 CASP1

OMIM:147678 CASP1

UCSC:P29466 CASP1

Reference Transcript

Other Identifiers

0004010524

0005360593

11732870_a_at

11738884_x_at

11741076_a_at

11741885_x_at

11742386_a_at

11750552_s_at

11750553_x_at

11763186_at

1552703_s_at

16743890

1BMQ

1IBC

1ICE

1RWK

1RWM

1RWN

1RWO

1RWP

1RWV

1RWW

1RWX

1SC1

1SC3

1SC4

206011_at

209970_x_at

211366_x_at

211367_s_at

211368_s_at

2685

2FQQ

2H48

2H4W

2H4Y

2H51

2H54

2HBQ

2HBR

2HBY

2HBZ

3056

3389354

3389355

3389356

3389357

3389358

3389359

3389360

3389361

3389364

3389365

3389366

3389367

3389369

3389370

3389371

3389372

3389373

3389375

3389399

3389409

3389458

3389459

3389464

39320_at

3D6F

3D6H

3D6M

3E4C

3NS7

574_s_at

5FNA

5MMV

5MTK

6BZ9

6F6R

7951397

834

A0A1W2PRX7

A_23_P202978

AAA66942

AAC50107

AAC50108

AAC50109

AAC50110

AAH41689

AAH62327

AAT72297

AK223503

AP001153

AY660536

B4DVD8

BAD97223

BC041689

BC062327

CAA46153

CAB002685

CASP1

CASP1-201

CASP1-202

CASP1-203

CASP1-204

CASP1-206

CASP1-212

CASP1-215

CASP1-216

CCDS53704

CCDS8329

CCDS8330

CCDS8331

CCDS8332

ENSG00000137752

ENSP00000344132

ENSP00000403260

ENSP00000410076

ENSP00000433138

ENSP00000434250

ENSP00000434303

ENSP00000434779

ENSP00000436875

ENST00000353247

ENST00000353247.9

ENST00000436863

ENST00000436863.7

ENST00000446369

ENST00000446369.5

ENST00000525825

ENST00000525825.5

ENST00000526568

ENST00000526568.5

ENST00000531166

ENST00000531166.5

ENST00000533400

ENST00000533400.5

ENST00000534497

ENST00000534497.5

EntrezGene:834

EntrezGene:CASP1

G3V169

g717041_3p_a_at

GE58945

GO:0002376

GO:0003674

GO:0004175

GO:0004197

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0006810

GO:0006915

GO:0006919

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0008233

GO:0008234

GO:0008656

GO:0016020

GO:0016540

GO:0016787

GO:0019221

GO:0019899

GO:0019900

GO:0030234

GO:0032731

GO:0032991

GO:0042802

GO:0042981

GO:0043123

GO:0043280

GO:0050700

GO:0050718

GO:0051604

GO:0071222

GO:0071260

GO:0071310

GO:0071345

GO:0071346

GO:0072557

GO:0072558

GO:0072559

GO:0097153

GO:0097169

GO:0097179

GO:0097190

GO:0097194

GO:0097199

GO:1903265

H0YEC7

HGNC:1499

HPA003056

Hs.2490.0.S2_3p_at

Hs2.348365.1.S1_3p_s_at

ILMN_1727762

ILMN_1742270

ILMN_2326509

ILMN_2326512

IPR001309

IPR001315

IPR002138

IPR002398

IPR011029

IPR015917

IPR016129

IPR029030

IPR033139

M87507

M87507_s_at

MIM:147678

NM_001223

NM_001257118

NM_001257119

NM_033292

NM_033293

NM_033294

NM_033295

NP_001214

NP_001244047

NP_001244048

NP_150634

NP_150635

NP_150636

NP_150637

PF00619

PF00656

PH_hs_0000334

PH_hs_0029807

PH_hs_0030886

PR00376

Q5FBZ0

SM00114

SM00115

TC11003505.hg

U13697

U13698

U13699

U13700

UPI000002AB7F

UPI000002AB80

UPI000002AB81

UPI000002AB82

UPI000003AEF8

X65019

XM_017018393

XM_017018394

XM_017018395

XM_017018396

XP_016873882

XP_016873883

XP_016873884

XP_016873885

Participant Of

output

CTSG cleaves CASP1(1-404)

input

Formation of caspase-1 p10/p20 dimer

hasComponent

CASP1(120-197):CASP1(317-404) [cytosol]

Other forms of this molecule

CASP1(1-119) [cytosol]

CASP1(298-316) [cytosol]

CASP1(120-297) [cytosol]

CASP1(1-404) [cytosol]

Inferred To

CASP1(317-404) [cytosol] (Caenorhabditis elegans)

CASP1(317-404) [cytosol] (Danio rerio)

CASP1(317-404) [cytosol] (Drosophila melanogaster)

CASP1(317-404) [cytosol] (Gallus gallus)

CASP1(317-404) [cytosol] (Mus musculus)

CASP1(317-404) [cytosol] (Rattus norvegicus)

CASP1(317-404) [cytosol] (Xenopus tropicalis)

Homologues of CASP1(317-404) [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001214.1, NP_001244047.1, NP_150634.1, NP_150636.1, NP_150635.1, NP_001244048.1, NP_150637.1

ZINC - World Drugs

CASP1_HUMAN

OpenTargets

ENSG00000137752

ZINC - FDA approved

CASP1_HUMAN

ZINC - Substances

CASP1_HUMAN

ZINC target

P29466

ZINC - Biogenic

CASP1_HUMAN

PRO

P29466

PDB

1SC4, 1IBC, 1RWO, 2H4W, 3D6M, 1RWM, 1SC3, 5MMV, 1RWX, 6F6R, 1RWN, 1BMQ, 6BZ9, 1RWV, 5MTK, 5FNA, 3E4C, 3D6H, 1ICE, 3NS7, 1RWW, 1RWK, 1SC1, 2FQQ, 2HBY, 2HBQ, 3D6F, 2H4Y, 1RWP, 2H51, 2HBZ, 2HBR, 2H54, 2H48

ZINC - Investigational

CASP1_HUMAN

ZINC - Metabolites

CASP1_HUMAN

GeneCards

P29466

Orphanet

24389

ZINC - Predictions - Purchasable

CASP1_HUMAN

HMDB Protein

HMDBP02162

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD	4	PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [cytosol] (R-HSA-561191)	0.765	9
UniProt:Q9NPP4 NLRC4	1	NLRC4 [cytosol] (R-HSA-561198)	0.743	4
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.656	3
UniProt:P57730 CAR18			0.598	3
UniProt:Q5XLA6 CAR17			0.591	3
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.591	4
UniProt:P29466 CASP1	5	CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(1-404) [cytosol] (R-HSA-448692)	0.587	2
UniProt:P58753-2 TIRAP			0.581	5
UniProt:Q08AM6 VAC14	3	VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219) VAC14 [Golgi membrane] (R-HSA-1806235)	0.556	3
UniProt:P01583 IL1A	4	IL1A(1-271) [cytosol] (R-HSA-449042) IL1A(1-112) [cytosol] (R-HSA-449059) 2xMyri-IL1A [cytosol] (R-HSA-449054) Myr82K-Myr83K-IL1A [extracellular region] (R-HSA-445746)	0.524	3
UniProt:O14862 AIM2	1	AIM2 [cytosol] (R-HSA-874111)	0.488	2