Reactome | Interleukin-27 translocates from the ER lumen to the extracellular region

Interleukin-27 translocates from the ER lumen to the extracellular region

Stable Identifier

R-HSA-448421

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, endoplasmic reticulum lumen

Synonyms

IL27:EBI3 (IL27) is secreted to the extracellular space

ReviewStatus

5/5

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Interleukin-27 translocates from the ER lumen to the extracellular region

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When Interleukin-27 subunit beta (EBI3) was expressed in cells, it accumulated in the endoplasmic reticulum and associated with the molecular chaperone calnexin(CANX), indicating that subsequent processing and secretion might be dependent on association with a second subunit (Devergne et al.1996)
Interleukin-27 subunit alpha (IL27) coexpressed with EBI3 permitted secretion as a soluble complex (Pflanz et al. 2002)

This is a black box event because there is not reported evidene about the mechanism of the traslocation of the IL-27 heterodimer from the endoplasmic reticulum to the extracellular region.

Literature References

PubMed ID	Title	Journal	Year
12121660	IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells Vaisberg, E, Gorman, DM, Timans, JC, Gilbert, J, Mattson, JD, Hibbert, L, Travis, M, Rennick, D, To, W, Kastelein, RA, Kanzler, H, Zurawski, S, Cheung, J, Rosales, R, Pflanz, S, Wagner, JL, Blumenschein, WM, Bazan, JF, de Waal Malefyt, R, Churakova, T, McClanahan, TK	Immunity	2002