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MYLK(1-1914) [cytosol]
Stable Identifier
R-HSA-445807
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Myosin light chain kinase, smooth muscle, MYLK, MYLK_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)
MYLK(1-1914) [cytosol] (Homo sapiens)
MYLK:Ca2+:CALM1 [cytosol] (Homo sapiens)
MYLK(1-1914) [cytosol] (Homo sapiens)
Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
MYLK:Ca2+:CALM1 [cytosol] (Homo sapiens)
MYLK(1-1914) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)
MYLK(1-1914) [cytosol] (Homo sapiens)
MYLK:Ca2+:CALM1 [cytosol] (Homo sapiens)
MYLK(1-1914) [cytosol] (Homo sapiens)
MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
MYLK:Ca2+:CALM1 [cytosol] (Homo sapiens)
MYLK(1-1914) [cytosol] (Homo sapiens)
PAK1 or PAK2 phosphorylates MYLK (Homo sapiens)
MYLK(1-1914) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15746 MYLK
Gene Names
MYLK, MLCK, MLCK1, MYLK1
Chain
initiator methionine:, initiator methionine:, chain:1-1914, chain:1-1910
Reference Genes
BioGPS Gene:4638 MYLK
COSMIC (genes):MYLK MYLK
CTD Gene:4638 MYLK
dbSNP Gene:4638 MYLK
ENSEMBL:ENSG00000065534 MYLK
ENSEMBL_homo_sapiens_GENE:ENSG00000065534.20 MYLK
HGNC:7590 MYLK
KEGG Gene (Homo sapiens):4638 MYLK
Monarch:4638 MYLK
NCBI Gene:4638 MYLK
OMIM:600922 MYLK
UCSC:Q15746 MYLK
Reference Transcript
RefSeq:NM_053028.3 MYLK
RefSeq:XM_017006473.1 MYLK
RefSeq:XM_017006469.1 MYLK
RefSeq:NM_053032.3 MYLK
RefSeq:NM_053027.3 MYLK
RefSeq:NM_053025.3 MYLK
RefSeq:XM_017006472.1 MYLK
RefSeq:XM_011512860.2 MYLK
RefSeq:NM_053031.3 MYLK
RefSeq:XM_017006471.1 MYLK
RefSeq:NM_001321309.1 MYLK
RefSeq:NM_053026.3 MYLK
Other Identifiers
11721837_a_at
11727361_a_at
11757621_a_at
1569956_PM_at
1569956_at
16958251
202555_PM_s_at
202555_s_at
224823_PM_at
224823_at
2640092
2683093
2683095
2683103
2692442
2692444
2692446
2692448
2692449
2692450
2692451
2692452
2692455
2692457
2692458
2692459
2692460
2692461
2692462
2692463
2692464
2692465
2692467
2692468
2692469
2692474
2692475
2692476
2692478
2692483
2692484
2692485
2692487
2692489
2692493
2692494
2692495
2692498
2692499
2692500
2692501
2692502
2692503
2692509
2692510
2692511
2692515
2692516
2692524
2692525
2692526
2692529
2692530
2692531
2692532
2692536
2692537
2692538
2692540
2692551
2692552
2692559
2692560
2692561
2692566
2692569
2692570
32847_at
46276_at
4638
8090098
91006_at
A_23_P143817
A_24_P319923
GE62311
GE81581
GO:0000166
GO:0001725
GO:0003012
GO:0003779
GO:0003824
GO:0004672
GO:0004674
GO:0004687
GO:0005515
GO:0005516
GO:0005524
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006939
GO:0008092
GO:0014820
GO:0015629
GO:0016301
GO:0016310
GO:0016740
GO:0030027
GO:0030335
GO:0032060
GO:0032154
GO:0036211
GO:0042060
GO:0042995
GO:0043226
GO:0046872
GO:0048856
GO:0048870
GO:0051928
GO:0060414
GO:0071476
GO:0090303
GO:0140096
HMNXSV003000993
Hs.288965.0.S1_3p_at
Hs2.382024.1.S1_3p_at
ILMN_1663427
ILMN_1691476
ILMN_2364768
PH_hs_0026578
TC03001713.hg
TC03003055.hg
TC03003056.hg
TC03003057.hg
U48959_at
g5174600_3p_a_at
Participates
as an input of
PAK1 or PAK2 phosphorylates MYLK (Homo sapiens)
MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)
as a component of
MYLK:Ca2+:CALM1 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S1208,S1759-MYLK(1-1914) [cytosol]
Inferred To
MYLK(1-1914) [cytosol]
(Bos taurus)
MYLK(1-1914) [cytosol]
(Canis familiaris)
MYLK(1-1914) [cytosol]
(Gallus gallus)
MYLK(1-1914) [cytosol]
(Mus musculus)
MYLK(1-1914) [cytosol]
(Rattus norvegicus)
MYLK(1-1914) [cytosol]
(Sus scrofa)
MYLK(1-1914) [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001308238.1
,
NP_444253.3
,
XP_016861958.1
,
NP_444259.1
,
XP_016861960.1
,
XP_016861962.1
,
NP_444260.1
,
NP_444255.3
,
XP_016861961.1
,
XP_011511162.1
,
NP_444254.3
,
NP_444256.3
Guide to Pharmacology - Targets
1552
OpenTargets
ENSG00000065534
HPA
ENSG00000065534-MYLK
GeneCards
Q15746
ZINC target
Q15746
Ensembl
ENST00000693689
,
ENST00000685021
,
ENSP00000509867
,
ENSP00000509803
,
ENST00000418370
,
ENST00000346322
,
ENST00000583087
,
ENSP00000508758
,
ENSG00000065534
,
ENSP00000509044
,
ENSP00000353452
,
ENSP00000354004
,
ENST00000508240
,
ENST00000360772
,
ENSP00000462118
,
ENSP00000508447
,
ENST00000686406
,
ENST00000688024
,
ENST00000686761
,
ENSP00000510047
,
ENSP00000510503
,
ENST00000687375
,
ENSP00000320622
,
ENST00000685744
,
ENSP00000422984
,
ENSP00000428967
,
ENST00000360304
PRO
Q15746
Pharos - Targets
Q15746
Orphanet
19503
PDB
5JQA
,
2CQV
,
2YR3
,
5JTH
,
6C6M
,
2K0F
HMDB Protein
HMDBP01417
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HD26 GOPC
3
GOPC [lysosomal membrane]
(R-HSA-5627281)
GOPC [plasma membrane]
(R-HSA-5626572)
GOPC [Golgi-associated vesicle membrane]
(R-HSA-5627067)
0.556
3
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