Reactome | ATP Hydrolysis By Myosin

ATP Hydrolysis By Myosin

Stable Identifier

R-HSA-445699

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Once ATP is bound, myosin, which is an ATPase, uses the energy from the cleavage of the terminal phosphate to pivot the myosin head back, away from the actin filamentous chain. This change in conformation "resets" the myosin molecule, leaving it ready to bind the actin filament once more and slide the myosin filament along the actin filament, continuing the contractile cycle.

Literature References

PubMed ID	Title	Journal	Year
2526655	Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells Kumar, CC, Leibowitz, PJ, Zavodny, PJ, Mohan, SR, Narula, SK	Biochemistry	1989
3780718	Isoforms of myosin and actin in human, monkey and rat myometrium. Comparison of pregnant and non-pregnant uterus proteins d'Albis, A, Ropert, S, Janmot, C, Cavaillé, F	Eur J Biochem	1986