Phosphorylation of Y1229 in L1

Stable Identifier
R-HSA-445076
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of Y1229 in L1
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Binding of ankyrins is dependent on the phosphorylation and dephosphorylation state of the tyrosine in the L1 FIGQY motif. In the dephosphorylated state ankyrins bind to L1 and in the phosphorylated state L1 releases from ankyrins and binds to doublecortin.
The specific kinase that is responsible for the phosphorylation of this tyrosine residue is still unknown, but components of the MAP kinase pathway may regulate this event. Tyrosine phosphorylation abolishes ankyrin binding and also increases L1 lateral mobility and neurite growth
Literature References
PubMed ID Title Journal Year
16597699 MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth

Gazdoiu, M, Sakurai, T, Felsenfeld, DP, Cassella, MR, Whittard, JD

Mol Biol Cell 2006
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Catalyst Activity

protein tyrosine kinase activity of unidentified protein tyrosine kinase [cytosol]

Physical Entity
unidentified protein tyrosine kinase [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
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