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CCL4(24-92) [extracellular region]
Stable Identifier
R-HSA-443976
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CCL4, C-C motif chemokine 4, CCL4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)
ACKR2:CCBP2 ligands [plasma membrane] (Homo sapiens)
CCBP2 ligands [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
CCBP2 ligands [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13236 CCL4
Gene Names
CCL4, LAG1, MIP1B, SCYA4
Chain
signal peptide:1-23, chain:24-92, chain:26-92
Reference Genes
BioGPS Gene:388372 CCL4
BioGPS Gene:6351 CCL4
CTD Gene:388372 CCL4
CTD Gene:6351 CCL4
dbSNP Gene:388372 CCL4
dbSNP Gene:6351 CCL4
ENSEMBL:ENSG00000275302 CCL4
ENSEMBL_homo_sapiens_GENE:ENSG00000275302.2 CCL4
ENSEMBL_homo_sapiens_GENE:ENSG00000275824.4 CCL4
ENSEMBL_homo_sapiens_GENE:ENSG00000277943.4 CCL4
HGNC:10630 CCL4
KEGG Gene (Homo sapiens):388372 CCL4
KEGG Gene (Homo sapiens):6351 CCL4
Monarch:388372 CCL4
Monarch:6351 CCL4
NCBI Gene:388372 CCL4
NCBI Gene:6351 CCL4
OMIM:182284 CCL4
UCSC:P13236 CCL4
Reference Transcript
RefSeq:NM_207007.3 CCL4
RefSeq:NM_002984.3 CCL4
Other Identifiers
11718982_s_at
11718983_x_at
11746954_s_at
16833420
16833433
204103_PM_at
204103_at
36674_at
3718931
3718932
3718935
3718937
3718938
3718979
3718980
3718982
3718985
3718986
3719025
3719026
3719028
3719030
3719031
4040064
4040065
4040067
4040070
4040071
6351
8006602
8006608
8006621
8019651
A_23_P207564
A_33_P3354607
GE57501
GO:0002376
GO:0002548
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006954
GO:0006955
GO:0007155
GO:0007163
GO:0007165
GO:0007186
GO:0007267
GO:0008009
GO:0009615
GO:0009636
GO:0023052
GO:0030593
GO:0031726
GO:0031730
GO:0042802
GO:0043922
GO:0048018
GO:0048020
GO:0048245
GO:0048247
GO:0048870
GO:0050850
GO:0051928
GO:0070098
GO:0070374
GO:0071346
GO:0071347
GO:0071356
GO:0098542
GO:0098772
GO:2000503
HMNXSV003012806
ILMN_1716276
J04130_s_at
M69203_s_at
PH_hs_0028969
PH_hs_0039822
TC17000408.hg
g4506844_3p_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CCBP2 ligands [extracellular region] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
Inferred To
CCL4(24-92) [extracellular region]
(Gallus gallus)
CCL4 [extracellular region]
(Bos taurus)
CCL4 [extracellular region]
(Canis familiaris)
CCL4 [extracellular region]
(Sus scrofa)
Ccl4 [extracellular region]
(Mus musculus)
Ccl4 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_002975.1
,
NP_996890.1
OpenTargets
ENSG00000275302
HPA
ENSG00000275302-CCL4
GeneCards
P13236
Ensembl
ENST00000617322
,
ENSG00000275824
,
ENST00000621600
,
ENSP00000478708
,
ENSP00000482259
,
ENSP00000480345
,
ENSG00000275302
,
ENSG00000277943
,
ENST00000615863
PRO
P13236
Pharos - Targets
P13236
PDB
3TN2
,
2FFK
,
1HUM
,
2X6L
,
4RAL
,
2FIN
,
1HUN
,
1JE4
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [endosome membrane]
(R-HSA-435363)
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
0.781
8
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q8IWU4 SLC30A8
2
SLC30A8 [Golgi membrane]
(R-HSA-9817561)
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:Q6IN84 MRM1
1
MRM1 [mitochondrial matrix]
(R-HSA-6793088)
0.556
3
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
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