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FZD2 [plasma membrane]
Stable Identifier
R-HSA-443945
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Frizzled-2, FZD2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Frizzled receptors bind Wnts (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
Frizzled receptors:WNTs [plasma membrane] (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
FZD recruits trimeric G-proteins (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Homo sapiens)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)
WNT5A:FZDs/ROR [plasma membrane] (Homo sapiens)
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A binds FZD and ROR receptors (Homo sapiens)
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT5A:FZDs/ROR [plasma membrane] (Homo sapiens)
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
FZD recruits DVL to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14332 FZD2
Gene Names
FZD2
Chain
signal peptide:1-23, chain:24-565
Reference Genes
BioGPS Gene:2535 FZD2
COSMIC (genes):FZD2 FZD2
CTD Gene:2535 FZD2
dbSNP Gene:2535 FZD2
ENSEMBL:ENSG00000180340 FZD2
ENSEMBL_homo_sapiens_GENE:ENSG00000180340.7 FZD2
HGNC:4040 FZD2
KEGG Gene (Homo sapiens):2535 FZD2
Monarch:2535 FZD2
NCBI Gene:2535 FZD2
OMIM:600667 FZD2
UCSC:Q14332 FZD2
Reference Transcript
RefSeq:NM_001466.3 FZD2
Other Identifiers
11727552_at
16834785
210220_PM_at
210220_at
238129_PM_s_at
238129_s_at
2535
36799_at
3723009
3723010
3723011
3723012
3723013
3723014
3723015
3723016
3723017
3723018
46871_r_at
61063_at
628_at
8007637
A_14_P126073
A_23_P141362
GE58254
GO:0003149
GO:0003150
GO:0003151
GO:0004888
GO:0004930
GO:0005515
GO:0005737
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0007165
GO:0007166
GO:0007186
GO:0007267
GO:0007608
GO:0016020
GO:0016055
GO:0017147
GO:0023052
GO:0030154
GO:0030165
GO:0030182
GO:0030669
GO:0031410
GO:0035567
GO:0042813
GO:0043226
GO:0045446
GO:0045893
GO:0048856
GO:0050877
GO:0051091
GO:0060022
GO:0060070
GO:0060071
GO:0060089
GO:0060119
GO:0060412
GO:0090103
GO:0090179
HMNXSV003007369
Hs.142912.0.A1_3p_at
ILMN_1653711
L37882_at
PH_hs_0031791
TC17000571.hg
g736678_3p_at
Participates
as a candidate of
Frizzled receptors [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
as a member of
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
Other forms of this molecule
FZD2 [clathrin-coated endocytic vesicle membrane]
Inferred To
fzd2 [plasma membrane]
(Xenopus tropicalis)
FZD2 [plasma membrane]
(Bos taurus)
FZD2 [plasma membrane]
(Canis familiaris)
FZD2 [plasma membrane]
(Gallus gallus)
FZD2 [plasma membrane]
(Sus scrofa)
fz [plasma membrane]
(Drosophila melanogaster)
mom-5 [plasma membrane]
(Caenorhabditis elegans)
zfz2 [plasma membrane]
(Danio rerio)
Fzd2 [plasma membrane]
(Mus musculus)
Fzd2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001457.1
Guide to Pharmacology - Targets
230
OpenTargets
ENSG00000180340
GeneCards
Q14332
HPA
ENSG00000180340-FZD2
Ensembl
ENSG00000180340
,
ENSP00000323901
,
ENST00000315323
PRO
Q14332
Pharos - Targets
Q14332
Orphanet
23281
HMDB Protein
HMDBP07698
PDB
7N95
,
7N9S
,
7X8P
,
7N97
,
6C0B
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P39688 Fyn
6
Fyn [cytosol]
(R-MMU-420333)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
phospho-p-Y420-FYN [cytosol]
(R-MMU-391821)
pFyn(Y531) [cytosol]
(R-MMU-420350)
pFyn (420) [cytosol]
(R-MMU-420335)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
0.525
4
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