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p-Y172-VAV2 [cytosol]
Stable Identifier
R-HSA-442307
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-VAV2(Y172)
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
SFKs phosphorylate VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
L1CAM interactions (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
Activation of Rac1 by VAV2 (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Phosphorylation of VAV2 (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
VAV2 is a GEF for Rho/Rac family kinases (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-Y348-SYK phosphorylates VAV family (Homo sapiens)
p-Y348-SYK:p-VAV family [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Activation of RAC1 by VAV2/3 (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Phosphorylation of VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
Src kinases phosphorylate VAV (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
PAK1-3 autophosphorylates (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
PAK1-3 dimer disassociates (Homo sapiens)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
RAC1 binds PAK1-3 (Homo sapiens)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52735 VAV2
Gene Names
VAV2
Chain
chain:1-878
Reference Genes
BioGPS Gene:7410 VAV2
COSMIC (genes):VAV2 VAV2
CTD Gene:7410 VAV2
dbSNP Gene:7410 VAV2
ENSEMBL:ENSG00000160293 VAV2
ENSEMBL_homo_sapiens_GENE:ENSG00000160293.17 VAV2
HGNC:12658 VAV2
KEGG Gene (Homo sapiens):7410 VAV2
Monarch:7410 VAV2
NCBI Gene:7410 VAV2
OMIM:600428 VAV2
UCSC:P52735 VAV2
Reference Transcript
RefSeq:NM_003371.3 VAV2
RefSeq:NM_001134398.1 VAV2
RefSeq:XM_005272213.1 VAV2
Other Identifiers
11736808_a_at
11736809_a_at
11744302_a_at
1704_at
17099617
205536_PM_at
205536_at
205537_PM_s_at
205537_s_at
226063_PM_at
226063_at
3228885
3228886
3228887
3228890
3228892
3228893
3228895
3228896
3228897
3228898
3228899
3228910
3228911
3228912
3228916
3228917
3228922
3228924
3228925
3228927
3228936
3228941
3228948
3228955
3228969
3228978
3228990
3229000
52054_at
7410
8164967
A_23_P146468
A_24_P84419
GE79585
GO:0001525
GO:0001784
GO:0002376
GO:0005085
GO:0005154
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0007264
GO:0008361
GO:0016192
GO:0016477
GO:0023052
GO:0030031
GO:0030032
GO:0030168
GO:0035556
GO:0038095
GO:0038096
GO:0042060
GO:0043087
GO:0046872
GO:0048010
GO:0048856
GO:0048870
GO:0051056
GO:0051897
GO:0071466
GO:0098772
HMNXSV003001416
Hs.4248.0.S2_3p_at
Hs.4248.0.S2_3p_x_at
Hs.4248.1.S1_3p_at
ILMN_1794781
PH_hs_0000469
S76992_at
TC09001696.hg
g4507870_3p_a_at
p26514
Participates
as an output of
Phosphorylation of VAV2 (Homo sapiens)
as a member of
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
Other forms of this molecule
VAV2 [cytosol]
Inferred To
phospho-p-Y172-VAV2 [cytosol]
(Gallus gallus)
phospho-Vav [cytosol]
(Drosophila melanogaster)
phospho-vav-1 [cytosol]
(Caenorhabditis elegans)
phospho-Vav2 [cytosol]
(Mus musculus)
phospho-Vav2 [cytosol]
(Rattus norvegicus)
phospho-VAV2 [cytosol]
(Bos taurus)
phospho-VAV2 [cytosol]
(Canis familiaris)
phospho-VAV2 [cytosol]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 172
Coordinate
172
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_005272270.1
,
NP_001127870.1
,
NP_003362.2
OpenTargets
ENSG00000160293
GeneCards
P52735
HPA
ENSG00000160293-VAV2
Ensembl
ENST00000371851
,
ENSP00000385362
,
ENST00000406606
,
ENSP00000360916
,
ENST00000371850
,
ENSP00000360917
,
ENSG00000160293
PRO
P52735
Pharos - Targets
P52735
HMDB Protein
HMDBP10954
PDB
4ROJ
,
7RNV
,
2LNW
,
2DM1
,
2DLZ
,
2LNX
,
7WFY
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78314 3BP2
0.67
4
UniProt:Q9H3M7 TXNIP
2
TXNIP [nucleoplasm]
(R-HSA-9617747)
TXNIP [cytosol]
(R-HSA-1250246)
0.558
2
UniProt:Q8WZ42 TTN
2
TTN [extracellular region]
(R-HSA-350729)
TTN [cytosol]
(R-HSA-350726)
0.553
2
UniProt:O75674 TM1L1
0.508
2
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.499
2
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