TCF/LEF:CTNNB1 promote transcription of AXIN2

Stable Identifier
R-HSA-4411372
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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TCF/LEF:CTNNB1 promote transcription of AXIN2
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Each of the four TCF/LEF transcription factors have been shown to bind to the AXIN2 promoter in conjunction with beta-catenin to activate transcription (Park et al, 2009; Lustig et al, 2002; Jho et al, 2002, Leung et al 2002; Wohrle et al, 2007).
Literature References
PubMed ID Title Journal Year
17923689 Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors

Hecht, A, Wöhrle, S, Wallmen, B

Mol. Cell. Biol. 2007
11809809 Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

van De Wetering, M, Clevers, HC, Sachs, M, Jerchow, B, Pietsch, T, Lustig, B, Weiler, S, Birchmeier, W, Karsten, U, Schlag, PM, Behrens, J

Mol. Cell. Biol. 2002
11809808 Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

Domon, C, Jho, EH, Freund, JN, Joo, CK, Costantini, F, Zhang, T

Mol. Cell. Biol. 2002
19571879 Telomerase modulates Wnt signalling by association with target gene chromatin

Venteicher, AS, Park, JI, Jun, S, Artandi, SE, Nusse, R, Ji, H, Cheung, P, Veenstra, TD, Shkreli, M, Meng, Z, Choi, J, McLaughlin, M, Chang, W, Hong, JY, McCrea, PD

Nature 2009
11940574 Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

Zhai, Y, Kolligs, FT, Hanash, S, Wu, R, Fearon, ER, Cho, KR, Kuick, R, Leung, JY

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TCF/LEF:CTNNB1:AXIN2 gene [nucleoplasm] (Homo sapiens)
Active Unit
TCF/LEF:CTNNB1 [nucleoplasm]
Authored
Rothfels, K  (2013-08-24)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-08-24)
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