ZnT5 transports zinc into secretory granules in pancreatic beta cells

Stable Identifier
R-HSA-437085
Type
Reaction [transition]
Species
Homo sapiens
Compartment
secretory granule lumen, cytosol
ReviewStatus
5/5
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ZnT5 transports zinc into secretory granules in pancreatic beta cells
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The human gene SLC30A5 encodes the zinc transporter ZnT5. This protein is widely expressed but is most abundant in pancreatic beta cells (Kambe T et al, 2002). In these cells, ZnT5 mediates the transport of zinc into secretory granules that contain insulin.
Literature References
PubMed ID Title Journal Year
11904301 Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells

Kambe, T, Narita, H, Yamaguchi-Iwai, Y, Hirose, J, Amano, T, Sugiura, N, Sasaki, R, Mori, K, Iwanaga, T, Nagao, M

J Biol Chem 2002
Participants
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Output
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as an event of
Catalyst Activity

zinc ion transmembrane transporter activity of SLC30A5 [secretory granule membrane]

Physical Entity
SLC30A5 [secretory granule membrane] (Homo sapiens)
Activity
zinc ion transmembrane transporter activity (GO:0005385)
Orthologous Events
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Gallus gallus)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Mus musculus)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Rattus norvegicus)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Saccharomyces cerevisiae)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Schizosaccharomyces pombe)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Sus scrofa)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2009-09-11)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-11)
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