PIAS3 SUMOylates PGR with SUMO1

Stable Identifier
R-HSA-4341073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS3 SUMOylates PGR (Progesterone receptor, PR) at lysine-7, lysine-388, and lysine-531 with SUMO1 (Man et al. 2006, Daniel et al. 2007, Abdel-Hafiz et al. 2009). SUMOylation inhibits hormone-dependent transcription activation by PGR.

Literature References
PubMed ID Title Journal Year
19211567 Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation

Abdel-Hafiz, H, Dudevoir, ML, Horwitz, KB

J. Biol. Chem. 2009
17020914 PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus

Man, JH, Li, HY, Zhang, PJ, Zhou, T, He, K, Pan, X, Liang, B, Li, AL, Zhao, J, Gong, WL, Jin, BF, Xia, Q, Yu, M, Shen, BF, Zhang, XM

Nucleic Acids Res. 2006
17717077 Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells

Daniel, AR, Faivre, EJ, Lange, CA

Mol. Endocrinol. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created