SUMOylation of RARA with SUMO2

Stable Identifier
R-HSA-4341072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RARA (Retinoic acid receptor alpha) is SUMOylated at lysine-166, lysine-171, and lysine-399 with SUMO2 (Zhu et al. 2009). SUMOylation at lysine-166 and lysine-171 is induced by all-trans retinoic acid and inhibits nuclear localization of RARA. SUMOylation at lysine-399 is observed in the absence of all-trans retinoic acid and enhances nuclear localization of RARA. SUMOylation of all 3 sites inhibits transcriptional activation by RARA.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO2:UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created