SUMOylation of RXRA with SUMO1

Stable Identifier
R-HSA-4341048
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RXRA (Retinoid X receptor alpha) is SUMOylated at lysine-108 with SUMO1 (Choi et al. 2006). SUMOylation represses transcription activation by RXRA.

Literature References
PubMed ID Title Journal Year
16912044 Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1

Choi, SJ, Chung, SS, Rho, EJ, Lee, HW, Lee, MH, Choi, HS, Seol, JH, Baek, SH, Bang, OS, Chung, CH

J. Biol. Chem. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created