PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1

Stable Identifier
R-HSA-4341016
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1 SUMOylates NR3C2 (Mineralcorticoid receptor, MR) at lysine-89, lysine-399, lysine-428, and lysine 494 with SUMO1 (Tallec et al. 2003, Tirard et al. 2007, Yokota et al. 2007). SUMOylation represses the transcription activation activity of NR3C2.

Literature References
PubMed ID Title Journal Year
17314004 Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor

Tirard, M, Almeida, OF, Hutzler, P, Melchior, F, Michaelidis, TM

Mol. Cell. Endocrinol. 2007
17105732 Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9

Yokota, K, Shibata, H, Kurihara, I, Kobayashi, S, Suda, N, Murai-Takeda, A, Saito, I, Kitagawa, H, Kato, S, Saruta, T, Itoh, H

J. Biol. Chem. 2007
14500761 Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification

Tallec, LP, Kirsh, O, Lecomte, MC, Viengchareun, S, Zennaro, MC, Dejean, A, Lomb├Ęs, M

Mol. Endocrinol. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created